Foong Loke Kok, Zarringhalam Majid, Toghraie Davood, Izadpanahi Niloufar, Yan Shu-Rong, Rostami Sara
Institute of Smart Finance, Yango University, Fuzhou 350015, China.
Young Researchers and Elite Club, South Tehran Branch, Islamic Azad University, Tehran, Iran.
Comput Methods Programs Biomed. 2020 Sep;193:105457. doi: 10.1016/j.cmpb.2020.105457. Epub 2020 Mar 19.
In this work, using Sisko model, blood flow is simulated inside an artery which have cone shape of stenosis with different angles of φ = 0.25, φ = 0.5, φ = 0.75, φ = 1 and φ = 1.25 degree, respectively.
In the first step, an artery radius of 0.002 m is fixed to study the effects of cone shape of arterial stenosis on the flow behavior. Then, stenosis angle of φ = 0.5 degree is fixed to study the effects of different Artery radii of 0.002 m, 0.0025 m, 0.003m, and 0.0035 m orderly on the flow behavior. For simulation the blood flow, Sisko model is used. Afterward, stenosis angle of φ = 0.5 degrees with a radius of 0.002m is fixed for investigating the influences of different behavior of blood fluid by manipulation of constant parameters of the Sisko model.
It is reported that with increasing arterial stenosis angle, maximum blood flow velocity is sharply increased in central region of artery from 0.12 m/s to 0.16 m/s, 0.25 m/s, 0.36 m/s and 0.56 m/s in order of increasing stenosis angles from φ = 0.25 to φ = 0.5, φ = 0.75, φ = 1 and φ = 1.25 degree, respectively. Also, maximum shear stress of artery wall are as much as 64 Pa, 42 Pa, 24 Pa, 18 Pa and 16Pa respectively in order of stenosis angles of φ = 0.25, φ = 0.5, φ = 0.75, φ = 1 and φ = 1.25 degree. On the other side, the effect of increasing artery radius is against the influences of stenosis angle, and contradiction of these parameters is affected by the stress tension and viscosity of blood.
Variations of blood behavior from non-Newtonian to Newtonian shows that shear stress in blood stream in the stenosis artery with non-Newtonian blood is higher than that of Newtonian blood due to differences in their viscous behaviors and reactions in exposure of stenosis and artery wall effects.
在本研究中,使用西斯科模型对具有不同角度(分别为φ = 0.25度、φ = 0.5度、φ = 0.75度、φ = 1度和φ = 1.25度)锥形狭窄的动脉内的血流进行模拟。
第一步,固定动脉半径为0.002 m,以研究动脉狭窄的锥形对血流行为的影响。然后,固定狭窄角度为φ = 0.5度,依次研究不同动脉半径(0.002 m、0.0025 m、0.003 m和0.0035 m)对血流行为的影响。为了模拟血流,使用西斯科模型。之后,固定狭窄角度为φ = 0.5度且半径为0.002 m,通过操纵西斯科模型的常数参数来研究不同血液流体行为的影响。
据报道,随着动脉狭窄角度的增加,动脉中心区域的最大血流速度急剧增加,从0.12 m/s分别增加到0.16 m/s、0.25 m/s、0.36 m/s和0.56 m/s,狭窄角度从φ = 0.25度依次增加到φ = 0.5度、φ = 0.75度、φ = 1度和φ = 1.25度。此外,动脉壁的最大剪切应力分别为64 Pa、42 Pa、24 Pa、18 Pa和16 Pa,狭窄角度依次为φ = 0.25度、φ = 0.5度、φ = 0.75度、φ = 1度和φ = 1.25度。另一方面,动脉半径增加的影响与狭窄角度的影响相反,这些参数的矛盾受血液的应力张力和粘度影响。
血液行为从非牛顿流体变为牛顿流体的变化表明,由于狭窄动脉中血流的剪切应力在非牛顿血液和牛顿血液中的粘性行为及对狭窄和动脉壁效应暴露的反应不同,非牛顿血液中的剪切应力高于牛顿血液。