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应用牛顿和非牛顿方法对生物医学工程中施加恒定热通量的动脉内血流进行数值模拟。

Numerical simulation of blood flow inside an artery under applying constant heat flux using Newtonian and non-Newtonian approaches for biomedical engineering.

机构信息

Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam.

Department of Mechanical Engineering, Khomeinishahr Branch, Islamic Azad University, Khomeinishahr, Iran.

出版信息

Comput Methods Programs Biomed. 2020 Jul;190:105375. doi: 10.1016/j.cmpb.2020.105375. Epub 2020 Jan 31.

Abstract

BACKGROUND AND OBJECTIVE

In this paper, different behaviors of blood flow are simulated inside the artery under applying a constant heat flux on the artery boundary walls.

METHODS

To simulate the blood flow, the Sisko model is employed. Then, the temperature and Nusselt number of blood flow are reported for different Sisko parameters. Afterward, the effects of different artery radiuses are studied on the Nusselt number.

RESULTS

Medical treatment by replenishes fluid and electrolytes in the body vessels can change blood flow properties from non-Newtonian behavior to Newtonian behavior, which increases heat transfer in blood flow and causes to reduce blood flow temperature. In this research, the maximum temperature of Newtonian blood fluid flow is reported as much as 310.0045 K, whereas; maximum flow temperature in non-Newtonian blood fluid is 310.007 K. These results emphasize the effects of the type of Newtonian and non-Newtonian fluid model on the thermal behavior of blood inside body vessels. Since medical science does not permit body temperature to be changed from the normal condition, this small variation can be noticeable and sensible on the health. Hence, medical scientific research centers and institutes of vaccine and serum have to be careful in the mechanical design of drugs for blood fluid.

CONCLUSIONS

The results of this research show the application of mechanical engineering for some of the medical concerns in designing the drugs which are effective on the behavior of human body blood.

摘要

背景与目的

本文在动脉壁施加恒定热通量的情况下,模拟了血液在动脉内的不同流动行为。

方法

为了模拟血液流动,采用了 Sisko 模型。然后,报告了不同 Sisko 参数下的血流温度和努塞尔数。之后,研究了不同动脉半径对努塞尔数的影响。

结果

通过补充身体血管中的液体和电解质进行医疗治疗,可以将血液流动特性从非牛顿行为改变为牛顿行为,从而增加血液流动中的热量传递,并导致血液流动温度降低。在这项研究中,牛顿血液流体的最大温度报告为 310.0045 K,而非牛顿血液流体的最大流动温度为 310.007 K。这些结果强调了牛顿和非牛顿流体模型的类型对体内血管中血液热行为的影响。由于医学不允许体温从正常状态改变,这种微小的变化在健康方面可能是明显和敏感的。因此,疫苗和血清的医学科学研究中心和研究所必须在血液流体药物的机械设计中小心谨慎。

结论

本研究的结果表明,机械工程在设计对人体血液行为有效的药物方面可以应用于一些医疗关注问题。

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