冈达尔大学综合专科医院卫生专业人员对细胞毒性药物处理的知识及相关因素：基于机构的横断面研究。
Knowledge and associated factors towards cytotoxic drug handling among University of Gondar Comprehensive Specialized Hospital health professionals, institutional-based cross-sectional study.
机构信息
Department of Pharmaceutics, School of Pharmacy, University of Gondar, P.O.Box 196, Gondar, Ethiopia.
Department of Human Physiology, School of Medicine, University of Gondar, P.O.Box 196, Gondar, Ethiopia.
出版信息
Environ Health Prev Med. 2020 Apr 13;25(1):11. doi: 10.1186/s12199-020-00850-z.
BACKGROUND
Currently, cancer is among the leading causes of morbidity and mortality in the world. Exposure to CDs may occur during drug preparation and mixing, during drug administration, during transport, and cleaning spills and waste disposal. Healthcare workers who prepare or administer antineoplastic drugs, or who work in areas where these drugs are used, can be exposed to these agents. This also affects the public around the exposed area if appropriate disposal system is not known. Several studies reported increased risks of leukemia and breast cancer among nurses handling CDs and not following safety guidelines. Because of the absence of studies in Ethiopia, the current study was conducted to determine the knowledge level of cytotoxic drug handling and associated factors among health professionals in the University of Gondar Comprehensive Specialized Hospital.
METHODS
The institutional-based cross-sectional study was conducted from June to August 2019. Epi info 7.1 was used for data entry and then exported into SPSS version 20 for computing, recording, and statistical analysis. Logistic regression was used to explain the relationship with independent variables.
RESULTS
Four hundred and twelve health professionals participated in the study with 53.4% males. The participants' mean age was 29.9 (± 5.43) years ranging from 20-60. Two hundred and twenty-three (54.1%) health professionals heard about cytotoxic drugs, and 52.7% (95% UI 47.8-57.8%) had good knowledge of cytotoxic drug handling. Being male sex (AOR = 1.84, 95% CI (1.13-3.00)), age of 29-31 (AOR = 1.99, 95% CI (1.03-3.84)), hearing information about cytotoxic drug handling (AOR = 2.53, 95% CI (1.43-4.47)), ever attended training on cytotoxic drug handling (AOR = 3.15, 95% CI (1.13-8.79)), ever taking courses related to cytotoxic drugs (AOR = 2.03, 95% CI (1.15-3.59)), and good practice (AOR = 3.24, 95% CI (1.95-5.37)) were significantly associated with knowledge towards cytotoxic drug handling. It is therefore imperative to train health professionals and to incorporate CDs handling related course contents while revising curricula to raise the knowledge of health professionals about proper cytotoxic drug handling.
CONCLUSION
Above half of the study participants scored higher than the median of the cytotoxic drug handling knowledge questions. Sex, age, information about cytotoxic drug handling, training, taking courses related to cytotoxic drugs, and good practice were significantly associated with knowledge towards cytotoxic drugs handling.
背景
目前，癌症是世界上发病率和死亡率的主要原因之一。在药物准备和混合、给药、运输以及清理溢出物和废物处置过程中，可能会接触到 CDs。准备或给予抗肿瘤药物的医护人员，或在使用这些药物的区域工作的医护人员，可能会接触到这些药物。如果不知道适当的处理系统，暴露区域周围的公众也会受到影响。一些研究报告称，接触 CDs 且未遵守安全指南的护士中，白血病和乳腺癌的风险增加。由于在埃塞俄比亚没有研究，因此进行了当前的研究，以确定贡德尔大学综合专科医院卫生专业人员对细胞毒性药物处理的知识水平及其相关因素。
方法
这项基于机构的横断面研究于 2019 年 6 月至 8 月进行。使用 Epi info 7.1 进行数据输入，然后将其导出到 SPSS 版本 20 中进行计算、记录和统计分析。使用逻辑回归来解释与自变量的关系。
结果
412 名卫生专业人员参加了这项研究，其中 53.4%为男性。参与者的平均年龄为 29.9（±5.43）岁，年龄在 20-60 岁之间。223 名（54.1%）卫生专业人员听说过细胞毒性药物，其中 52.7%（95%置信区间[CI] 47.8-57.8%）对细胞毒性药物处理有良好的认识。男性（AOR=1.84，95%CI[1.13-3.00]）、年龄 29-31 岁（AOR=1.99，95%CI[1.03-3.84]）、听说过细胞毒性药物处理信息（AOR=2.53，95%CI[1.43-4.47]）、参加过细胞毒性药物处理培训（AOR=3.15，95%CI[1.13-8.79]）、参加过与细胞毒性药物相关的课程（AOR=2.03，95%CI[1.15-3.59]）和良好实践（AOR=3.24，95%CI[1.95-5.37]）与细胞毒性药物处理知识显著相关。因此，有必要培训卫生专业人员，并在修订课程时纳入与 CDs 处理相关的课程内容，以提高卫生专业人员对适当细胞毒性药物处理的认识。
结论
超过一半的研究参与者在细胞毒性药物处理知识问题的中位数以上得分较高。性别、年龄、细胞毒性药物处理信息、培训、参加与细胞毒性药物相关的课程以及良好的实践与细胞毒性药物处理知识显著相关。
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