Turku PET Centre, University of Turku, Turku, Finland; Department of Clinical Physiology, Nuclear Medicine and PET, Turku University Hospital, Turku, Finland.
Turku PET Centre, University of Turku, Turku, Finland; Department of Clinical Physiology, Nuclear Medicine and PET, Turku University Hospital, Turku, Finland.
Semin Nucl Med. 2020 May;50(3):238-247. doi: 10.1053/j.semnuclmed.2020.02.011. Epub 2020 Mar 4.
Myocardial perfusion imaging with 15O-water positron emission tomography (PET) is a validated tool for quantitative measurement of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Current scanner and software technology enable quantification of global and regional MBF in clinical PET myocardial perfusion imaging studies. Reduced stress MBF or MFR measured by 15O-water PET accurately detects hemodynamically significant coronary artery stenosis defined by intracoronary fractional flow reserve (FFR) measurement in patients with suspected obstructive coronary artery disease (CAD). Furthermore, MBF and MFR provide prognostic information on mortality and risk of myocardial infarction. Clinical experience in some centers indicates that clinical application of 15O-water PET in evaluation of CAD is feasible and guides management decisions on revascularization. This review discusses basic concepts of measuring MBF with 15O-water PET and reviews clinical studies on its application in evaluation of obstructive CAD.
15O-水正电子发射断层扫描（PET）心肌灌注成像可用于定量测量心肌血流（MBF）和心肌血流储备（MFR），这是一种经过验证的工具。目前的扫描仪和软件技术可实现临床 PET 心肌灌注成像研究中整体和局部 MBF 的定量。15O-水 PET 测量的应激状态下的 MBF 或 MFR 可准确检测到疑似阻塞性冠状动脉疾病（CAD）患者中以冠状动脉内血流储备分数（FFR）测量为定义的血流动力学意义上的显著冠状动脉狭窄。此外，MBF 和 MFR 可提供关于死亡率和心肌梗死风险的预后信息。一些中心的临床经验表明，15O-水 PET 在 CAD 评估中的临床应用是可行的，并指导了血运重建的管理决策。这篇综述讨论了使用 15O-水 PET 测量 MBF 的基本概念，并回顾了其在评估阻塞性 CAD 中的应用的临床研究。
