Isnardi V, Thureau S, Vera P
Department of Nuclear Medicine, centre Léon-Bérard, 28, promenade Léa-et-Napoléon-Bullukian, 69008 Lyon, France.
Department of Radiotherapy and Medical Physic, centre Henri-Becquerel, 1, rue d'Amiens, 76038 Rouen, France; Department of Nuclear Medicine Cancer, centre Henri-Becquerel, 1, rue d'Amiens, 76038 Rouen, France; Laboratoire QuantIF EA4108-Litis, université de Rouen, Rouen, France.
Cancer Radiother. 2020 Aug;24(5):362-367. doi: 10.1016/j.canrad.2020.03.006. Epub 2020 Apr 10.
Therapeutic effectiveness in radiotherapy is partly related to correct staging of the disease and then precise therapeutic targeting. Positron emission tomography (PET) allows the stage of many cancers to be determined and therefore is essential before deciding on radiation treatment. The definition of the therapeutic target is essential to obtain correct tumour control and limit side effects. The part of adaptive radiotherapy remains to be defined, but PET by its functional nature makes it possible to define the prognosis of many cancers and to consider radiotherapy adapted to the initial response allowing an increase over the entire metabolic volume, or targeted at a subvolume at risk per dose painting, or with a decrease in the dose in case of good response at interim assessment.
放射治疗的疗效部分与疾病的正确分期以及精确的治疗靶点有关。正电子发射断层扫描（PET）可确定许多癌症的分期，因此在决定放射治疗之前至关重要。治疗靶点的定义对于获得正确的肿瘤控制和限制副作用至关重要。自适应放射治疗的作用仍有待明确，但PET因其功能特性能够确定许多癌症的预后，并考虑根据初始反应调整放射治疗方案，例如增加整个代谢体积的照射剂量，或针对每剂量描绘的有风险亚体积进行靶向照射，或在中期评估显示良好反应时降低剂量。
