Department of Microbiology, Kansai Medical University, Osaka, 573-1010, Japan.
Division of Neuroimmunology, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima, 890-8544, Japan.
J Neurovirol. 2020 Jun;26(3):404-414. doi: 10.1007/s13365-020-00838-z. Epub 2020 Apr 13.
Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic myelopathy characterized by slowly progressive spastic paraparesis and urinary dysfunction. A few biomarkers in the cerebrospinal fluid are known to be related to disease activity, but no biomarker has been reported in peripheral blood. This study aims to explore the expression level of the adhesion molecule during the expression level of the adhesion molecule among HAM/TSP disease activity. In lymphocyte function-associated antigen 1 and DNAX accessory molecule 1, no variation in expression levels specific to HTLV-1 infection was observed in CD4-positive T cells; however, TSLC1 expression was higher in HAM patients than in asymptomatic carriers and non-infected persons. TSLC1 tended to be higher in patients whose symptoms were worsening. On the contrary, the expression level of TSLC1 in CD8-positive T cells was lower in HAM patients than in asymptomatic carriers, and this tendency was stronger in patients whose symptoms had deteriorated. No significant correlation was found between TSLC1 and either of the transcription factors Tax or HBZ in any T cell group. Therefore, TSLC1 expression in CD4-positive T cells might be a useful biomarker of HAM/TSP disease activity.
人嗜 T 淋巴细胞病毒 1 型（HTLV-1）相关脊髓病/热带痉挛性截瘫（HAM/TSP）是一种慢性脊髓病，其特征为进行性痉挛性截瘫和尿功能障碍。已知一些脑脊液中的生物标志物与疾病活动有关，但在外周血中尚未报道。本研究旨在探讨 HAM/TSP 疾病活动中粘附分子表达水平。在淋巴细胞功能相关抗原 1 和 DNAX 辅助分子 1 中，未观察到 CD4 阳性 T 细胞中针对 HTLV-1 感染的特异性表达水平变化；然而，TSLC1 在 HAM 患者中的表达水平高于无症状携带者和未感染者。TSLC1 在症状恶化的患者中倾向于更高。相反，HAM 患者的 CD8 阳性 T 细胞中 TSLC1 的表达水平低于无症状携带者，并且在症状恶化的患者中这种趋势更强。在任何 T 细胞群中，均未发现 TSLC1 与转录因子 Tax 或 HBZ 之间存在显著相关性。因此，CD4 阳性 T 细胞中的 TSLC1 表达可能是 HAM/TSP 疾病活动的有用生物标志物。
