Povoroznyuk Vladyslav V, Zaverukha Nataliia V, Musiienko Anna S
D. F. Chebotarev Institute Of Gerontology, Nams Of Ukraine, Kyiv, Ukraine.
Shupyk National Medical Academy Of Postgraduate Education, Kyiv, Ukraine, D. F. Chebotarev Institute Of Gerontology, Nams Of Ukraine, Kyiv, Ukraine.
Wiad Lek. 2020;73(3):529-533.
The aim of the study was to investigate the relationship between bone mineral density (BMD) of lumbar spine, femoral neck, trabecular bone score (TBS) and body mass index (BMI), in postmenopausal women with knee osteoarthritis (OA).
Materials and methods: The study group comprised 359 postmenopausal women aged 50-89 years. They were divided into 2 groups: I group - 117 postmenopausal women with symptomatic knee OA and II group -242 women with a normal functional activity of knee joints. Analysis of data was performed taking into account their BMD of lumbar spine (L1-L4) and femoral neck, measured by the Dual-energy X-ray absorptiometry (DXA) Hologic (Discovery WI, USA, 2016). TBS of L1-L4 was detected by TBS insight® software (MedImaps, Pessac, France), and BMI classified by World Health Organization (WHO).
Results: In postmenopausal women with obesity prevalence of symptomatic knee OA was detected in 41.1% of cases. However, in women with normal BMI knee OA was revealed in 29.0% of women. The highest level of knee OA in obese women aged 70-79 years - 45.8%. According to a chi-squared (χ2) test, a significantly higher level of BMI was detected in postmenopausal women with OA (χ2=5.05, p=0.02).
Conclusion: Women with a symptomatic OA had a significantly higher BMD of lumbar spine compared with women who had a normal functional activity of knee. Significant negative correlation were detected between TBS and BMI, and significant positive correlations between lumbar spine BMD and BMI.
本研究旨在调查绝经后膝骨关节炎（OA）女性腰椎骨密度（BMD）、股骨颈骨密度、小梁骨评分（TBS）与体重指数（BMI）之间的关系。
材料和方法：研究组包括359名年龄在50 - 89岁的绝经后女性。她们被分为两组：I组 - 117名有症状性膝OA的绝经后女性，II组 - 242名膝关节功能活动正常的女性。采用美国Hologic公司（2016年，Discovery WI）的双能X线吸收法（DXA）测量她们的腰椎（L1 - L4）和股骨颈骨密度，并进行数据分析。通过TBS insight®软件（法国梅迪马普斯公司，佩萨克）检测L1 - L4的TBS，并根据世界卫生组织（WHO）对BMI进行分类。
结果：在肥胖的绝经后女性中，41.1%的病例检测出有症状性膝OA。然而，在BMI正常的女性中，29.0%的女性患有膝OA。70 - 79岁肥胖女性的膝OA发生率最高 - 45.8%。根据卡方（χ2）检验，OA绝经后女性的BMI水平显著更高（χ2 = 5.05，p = 0.02）。
结论：有症状性OA的女性与膝关节功能活动正常的女性相比，腰椎骨密度显著更高。TBS与BMI之间存在显著负相关，腰椎骨密度与BMI之间存在显著正相关。
