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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Hisayama T, Shinkai M, Takayanagi I, Morimoto S, Ishida K

Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan.

Br J Pharmacol. 1988 Oct;95(2):459-64. doi: 10.1111/j.1476-5381.1988.tb11666.x.

Nicotine produced a transient contraction of rabbit isolated iris sphincter muscle, a parasympathetic ganglion-free tissue. The response to nicotine was antagonized by hexamethonium, but was insensitive to tetrodotoxin (TTX). While single treatments with atropine, capsaicin or [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-substance P (rpwwL-SP) partially blocked the response, combined treatment abolished it. 2. Chronic treatment of animals with nicotine added to the drinking water (about 12 mg kg-1 per day) had no effect on the responsiveness to nicotine or the pharmacological properties of nicotine-induced contraction. 3. These results suggest that acetylcholine and tachykinin(s) released via sodium channel-independent mechanisms from nerve terminals of parasympathetic and primary sensory nerves, respectively, are involved in the nicotine-induced contractile response.

尼古丁可使兔离体虹膜括约肌（一种不含副交感神经节的组织）产生短暂收缩。六甲铵可拮抗对尼古丁的反应，但对河豚毒素（TTX）不敏感。虽然单独使用阿托品、辣椒素或[D-精氨酸1，D-脯氨酸2，D-色氨酸7,9，亮氨酸11]-P物质（rpwwL-SP）可部分阻断该反应，但联合使用则可消除该反应。2. 给动物饮用添加尼古丁的水（约每天12毫克/千克）进行慢性处理，对其对尼古丁的反应性或尼古丁诱导收缩的药理学特性没有影响。3. 这些结果表明，分别通过与钠通道无关的机制从副交感神经和初级感觉神经的神经末梢释放的乙酰胆碱和速激肽参与了尼古丁诱导的收缩反应。

Hisayama T, Shinkai M, Takayanagi I, Morimoto S, Ishida K

Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan.

Br J Pharmacol. 1988 Oct;95(2):459-64. doi: 10.1111/j.1476-5381.1988.tb11666.x.

Nicotine produced a transient contraction of rabbit isolated iris sphincter muscle, a parasympathetic ganglion-free tissue. The response to nicotine was antagonized by hexamethonium, but was insensitive to tetrodotoxin (TTX). While single treatments with atropine, capsaicin or [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-substance P (rpwwL-SP) partially blocked the response, combined treatment abolished it. 2. Chronic treatment of animals with nicotine added to the drinking water (about 12 mg kg-1 per day) had no effect on the responsiveness to nicotine or the pharmacological properties of nicotine-induced contraction. 3. These results suggest that acetylcholine and tachykinin(s) released via sodium channel-independent mechanisms from nerve terminals of parasympathetic and primary sensory nerves, respectively, are involved in the nicotine-induced contractile response.

尼古丁可使兔离体虹膜括约肌（一种不含副交感神经节的组织）产生短暂收缩。六甲铵可拮抗对尼古丁的反应，但对河豚毒素（TTX）不敏感。虽然单独使用阿托品、辣椒素或[D-精氨酸1，D-脯氨酸2，D-色氨酸7,9，亮氨酸11]-P物质（rpwwL-SP）可部分阻断该反应，但联合使用则可消除该反应。2. 给动物饮用添加尼古丁的水（约每天12毫克/千克）进行慢性处理，对其对尼古丁的反应性或尼古丁诱导收缩的药理学特性没有影响。3. 这些结果表明，分别通过与钠通道无关的机制从副交感神经和初级感觉神经的神经末梢释放的乙酰胆碱和速激肽参与了尼古丁诱导的收缩反应。