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基于高分子双链RNA的抗病毒和抗肿瘤治疗药物的研发

Development of Drugs Based on High-Polymeric Double-Stranded RNA for Antiviral and Antitumor Therapy.

作者信息

Danilenko E D, Belkina A O, Sysoeva G M

机构信息

Institute of Medical Biotechnology, State Research Center of Virology and Biotechnology (SRC VB) "Vector", Khimzavodskaya ul. 9, 633010 Berdsk, Novosibirsk region Russia.

出版信息

Biochem Mosc Suppl B Biomed Chem. 2019;13(4):308-323. doi: 10.1134/S1990750819040036. Epub 2019 Dec 4.

DOI:10.1134/S1990750819040036
PMID:32288939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7104317/
Abstract

-The review summarizes literature data on the development of drugs based on natural and synthetic high-polymeric double-stranded RNA (dsRNA), their antiviral, immunoadjuvant, and antitumor properties. Special attention is paid to cell receptors responding to exogenous dsRNA, pathways of dsRNA-dependent antiviral reaction, ability of dsRNA to inhibit growth and induce apoptosis of malignant cells. It has been shown that enhancing the innate immune response with dsRNA can be an effective component in improving methods for treating and preventing infectious and cancer diseases. The further use of dsRNA for the correction of pathological processes of different origin is discussed.

摘要
  • 本综述总结了基于天然和合成高分子双链RNA（dsRNA）的药物研发的文献数据，及其抗病毒、免疫佐剂和抗肿瘤特性。特别关注对外源性dsRNA作出反应的细胞受体、dsRNA依赖性抗病毒反应途径、dsRNA抑制恶性细胞生长和诱导其凋亡的能力。研究表明，用dsRNA增强先天免疫反应可能是改进感染性疾病和癌症治疗及预防方法的有效组成部分。文中还讨论了dsRNA在纠正不同病因的病理过程中的进一步应用。
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ad/7104317/63880eb121bc/11828_2019_5042_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ad/7104317/d0b3f2e0d785/11828_2019_5042_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ad/7104317/7b6f8dffb0b0/11828_2019_5042_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ad/7104317/63880eb121bc/11828_2019_5042_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ad/7104317/d0b3f2e0d785/11828_2019_5042_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ad/7104317/7b6f8dffb0b0/11828_2019_5042_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ad/7104317/63880eb121bc/11828_2019_5042_Fig3_HTML.jpg

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Ezrin Peptide Therapy from HIV to COVID: Inhibition of Inflammation and Amplification of Adaptive Anti-Viral Immunity.埃兹蛋白肽治疗从 HIV 到 COVID：抑制炎症和增强适应性抗病毒免疫。
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