慢性给药于阳痿男性后“促性腺激素对释放激素反应性降低”
Reduced 'gonadotrophin response to releasing hormone' after chronic administration to impotent men.
作者信息
Davies T F, Gomez-Pan A, Watson M J, Mountjoy C Q, Hanker J P, Besser G M, Hall R
出版信息
Clin Endocrinol (Oxf). 1977 Mar;6(3):213-8. doi: 10.1111/j.1365-2265.1977.tb03317.x.
Ten endocrinologically normal men with secondary sexual impotence were given 500 microng LHRH subcutaneously every 8 h. After 4 weeks treatment the LH response to 500 microng LHRH was reduced from a peak of 35.7+/-5.2 to 16.8+/-3.5 mu/ml (P less than 0.01) and the FSH response from 4.2+/-0.93 to 2.39+/-0.4 mu/ml (P greater than 0.01). Circulating total testosterone, oestradiol, prolactin and sex hormone binding globulin showed no significant changes. Whether this inability of the pituitary to maintain it s response to LHRH is peculiar to impotent men requires further study.
10名内分泌功能正常但患有继发性性功能阳痿的男性，每8小时皮下注射500微克促性腺激素释放激素（LHRH）。经过4周治疗后，对500微克LHRH的促黄体生成素（LH）反应从峰值35.7±5.2降至16.8±3.5微国际单位/毫升（P<0.01），促卵泡生成素（FSH）反应从4.2±0.93降至2.39±0.4微国际单位/毫升（P>0.01）。循环中的总睾酮、雌二醇、催乳素和性激素结合球蛋白均无显著变化。垂体维持其对LHRH反应的这种无能是否为阳痿男性所特有，尚需进一步研究。
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