苯妥英钠和苯巴比妥在离体灌注人胎盘中的处置

Disposition of phenytoin and phenobarbitone in the isolated perfused human placenta.

Kluck R M, Cannell G R, Hooper W D, Eadie M J, Dickinson R G

Department of Medicine, University of Queensland, Royal Brisbane Hospital, Australia.

Clin Exp Pharmacol Physiol. 1988 Nov;15(11):827-36. doi: 10.1111/j.1440-1681.1988.tb01025.x.

Abstract

The disposition of the anti-epileptic agents phenytoin (PHT) and phenobarbitone (PB) was investigated in lobules of term human placentae perfused using separate maternal and fetal circulations for 6 h periods. 2. No evidence for metabolism of PHT or PB to their p-hydroxylated or other derivatives was found either in perfused lobules or by incubation with placental microsomes. 3. Both PHT and PB were readily transferred across the placenta after administration to either the maternal or fetal perfusates. 4. PHT, unlike PB, showed considerable accumulation in placental tissue.

摘要

使用单独的母体和胎儿循环对足月人胎盘小叶进行6小时灌注，研究抗癫痫药物苯妥英（PHT）和苯巴比妥（PB）的处置情况。2. 在灌注的小叶中或与胎盘微粒体孵育时，均未发现PHT或PB代谢为其对羟基化或其他衍生物的证据。3. 将PHT和PB分别给予母体或胎儿灌注液后，二者均易于穿过胎盘。4. 与PB不同，PHT在胎盘组织中显示出大量蓄积。