Friedberg V
Baillieres Clin Obstet Gynaecol. 1988 Dec;2(4):973-80. doi: 10.1016/s0950-3552(98)80024-2.
A total of 506 cases of cervical cancer, Stages Ib and IIb, operated on according to Wertheim and Meigs, were retrospectively (1972-1985) evaluated with respect to their clinical and morphological aspects. After 1978 a more intensive histological evaluation of the specimen was performed, resulting in the examination of a larger number of pelvic lymph nodes. The number of lymph nodes infiltrated depends on tumour stage, invasion depth, regional lymphovascular invasion of the tumour edge and parametria, and on haemangiosis carcinomatosa. The five-year survival rates were determined by the parametrial infiltration and by the number of positive pelvic lymph nodes. If neither the parametria nor the lymph nodes were infiltrated by the tumour the survival rate was 69%, whereas in cases of lymphovascular invasion of the parametria without infiltrated lymph nodes the rate decreases to 80%; in cases of tumour infiltration of both lymph nodes and parametria the cure rates are worst (62%). The operation on cervical cancer of Stages Ib and IIb with a thorough histological evaluation of the excised tissue therefore has a high prognostic value, but it also probably has better cure rates than is the case with radiological treatment.
对按照韦特海姆（Wertheim）和米格斯（Meigs）手术方法进行手术的506例Ib期和IIb期宫颈癌患者进行了回顾性（1972 - 1985年）临床和形态学方面的评估。1978年后，对标本进行了更深入的组织学评估，从而检查了更多的盆腔淋巴结。受浸润的淋巴结数量取决于肿瘤分期、浸润深度、肿瘤边缘和宫旁组织的区域淋巴管浸润以及癌性血行转移。五年生存率由宫旁浸润情况和盆腔阳性淋巴结数量决定。如果肿瘤既未浸润宫旁组织也未浸润淋巴结，生存率为69%；而在宫旁组织发生淋巴管浸润但淋巴结未受浸润的情况下，生存率降至80%；在淋巴结和宫旁组织均被肿瘤浸润的情况下，治愈率最差（62%）。因此，对Ib期和IIb期宫颈癌进行手术并对切除组织进行全面的组织学评估具有很高的预后价值，而且其治愈率可能也高于放射治疗。
