白细胞介素-6基因-174C/G和-634C/G多态性与尘肺病易感性关联的Meta分析

[Meta-analysis on association between interleukin-6-174C/G and -634C/G polymorphisms and pneumoconiosis susceptibility].

作者信息

Hao Yanxing, Li Jiangping, Shi Xinchen, Xie Qunhui, Zhao Bin, Xu Haiming, Yang Huifang

机构信息

Public Health and Management of Ningxia Medical University, Yinchuan 750004, China.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for EcoEnvironmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

出版信息

Wei Sheng Yan Jiu. 2020 Mar;49(2):185-189. doi: 10.19813/j.cnki.weishengyanjiu.2020.02.003.

DOI:10.19813/j.cnki.weishengyanjiu.2020.02.003

PMID:32290930

Abstract

OBJECTIVE

To explore the association between the interleukin-6-174 C/G and-634 C/G polymorphisms and pneumoconiosis susceptibility.

METHODS

Taking pneumoconiosis, interleukin-6, and polymorphism as keywords, Chinese literatures were retrieved among the Sinomed, Wanfang Medicine, CNKI and VIP databases, and foreign language literatures were retrieved among the Pubmed, Embase, Cochrane Library and Web of Science databases. Taking pneumoconiosis, susceptibility, and interleukin-6 as keywords, Revman 5. 2 software was employed to combine the genetic effects and evaluate the quality of the included literatures.

RESULTS

A total of seven literatures(containing nine case-control studies) were included, including 660 cases and 848 controls with IL-6-174 C/G polymorphism, and 344 cases and 362 controls with IL-6-634 C/G polymorphism. Meta-analysis shows that IL-6-174 C/G polymorphism is not associated with pneumoconiosis susceptibility(CC νs. CG+GG, OR=1. 05(95%CI 0. 76-1. 45), CG νs. GG+CC, OR=0. 79(95%CI 0. 40-1. 55), C νs. G, OR=0. 95(95% CI 0. 80-1. 14)), while IL-6-634 C/G polymorphism is associated with pneumoconiosis susceptibility(CC νs. CG+GG, OR=2. 12(95%CI 1. 56-2. 88), CG νs. GG+CC, OR=0. 40(95%CI 0. 27-0. 58), C νs. G, OR=1. 67(95%CI 1. 33-2. 11)).

CONCLUSION

There exists an association between the IL-6-634 C/G polymorphism and pneumoconiosis susceptibility, while there isn't an association between the IL-6-174 C/G polymorphism and the susceptibility of pneumoconiosis. IL-6-634 C/C genotype is pneumoconiosis-susceptible genotype.

摘要

目的

探讨白细胞介素-6（IL-6）基因-174C/G和-634C/G多态性与尘肺病易感性之间的关联。

方法

以“尘肺病”“白细胞介素-6”“多态性”为关键词，在中国生物医学文献数据库、万方医学数据库、中国知网数据库和维普数据库中检索中文文献；以“pneumoconiosis”“susceptibility”“interleukin-6”为关键词，在PubMed、Embase、Cochrane图书馆和科学引文索引数据库中检索外文文献。以“尘肺病”“易感性”“白细胞介素-6”为关键词，采用Revman 5.2软件合并基因效应并评价纳入文献的质量。

结果

共纳入7篇文献（包含9项病例对照研究），其中IL-6基因-174C/G多态性的病例660例、对照848例，IL-6基因-634C/G多态性的病例344例、对照362例。Meta分析结果显示，IL-6基因-174C/G多态性与尘肺病易感性无关（CC vs.CG+GG，OR=1.05（95%CI 0.76-1.45）；CG vs.GG+CC，OR=0.79（95%CI 0.40-1.55）；C vs.G，OR=0.95（95%CI 0.80-1.14）），而IL-6基因-634C/G多态性与尘肺病易感性有关（CC vs.CG+GG，OR=2.12（95%CI 1.56-2.88）；CG vs.GG+CC，OR=0.40（95%CI 0.27-0.58）；C vs.G，OR=1.67（95%CI 1.33-2.11））。