白细胞介素-1β +3953C/T、-511T/C多态性及白细胞介素-6 -174C/G多态性与结核病易感性的关联：一项荟萃分析
IL-1β+3953C/T, -511T/C and IL-6 -174C/G polymorphisms in association with tuberculosis susceptibility: A meta-analysis.
作者信息
Mao Xiaolu, Ke Zunqiong, Liu Shuiyi, Tang Beibei, Wang Jin, Huang Hao, Chen Song
机构信息
Department of Clinical Laboratory, Central Hospital of Wuhan, No. 26, Shengli Street, Jiangan District, Wuhan 430014, Hubei Province, PR China.
Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang Mid-Road, Shiyan 442000, Hubei Province, PR China.
出版信息
Gene. 2015 Nov 15;573(1):75-83. doi: 10.1016/j.gene.2015.07.025. Epub 2015 Jul 11.
BACKGROUND
Studies of the association between the interleukin-1β gene (IL-1β) (+3953C/T, -511T/C) and interleukin-6 gene (IL-6) (-174G/C) polymorphisms and susceptibility to tuberculosis (TB) have yielded inconsistent results. The aim of this study was to investigate the relationship between these polymorphisms and TB risk by this meta-analysis.
METHODS
We systematically searched published literatures on IL-1β gene and IL-6 gene polymorphisms and tuberculosis risk by the PubMed, Medline, Embase, Web of Science, Elsevier Science Direct and Cochrane Library databases, and identified outcome data from all articles. Statistical analysis was performed using Stata 12.0. A total of 15 studies comprising 3983TB patients and 3996 controls were included in the present study.
RESULTS
We found that the IL-6 -174C/G polymorphism might be associated with decreased risk of TB (C vs. G: OR=0.77, 95% CI=0.64-0.91; CG vs. GG: OR=0.72, 95% CI=0.57-0.90; CC+CG vs. GG: OR=0.71, 95% CI=0.57-0.88). In the stratified analysis by ethnicity, significantly decreased risk were observed for IL-1β -511T/C polymorphism in Africans (C allele vs. T allele: OR=0.86, 95% CI=0.74-0.99; CC vs. TT: OR=0.74, 95% CI=0.55-0.99). Moreover, the IL-6 -174 C/G polymorphism was also associated with decreased risk of TB in Asians (C vs. G: OR=0.71, 95% CI=0.54-0.93; CG vs. GG: OR=0.61, 95% CI=0.44-0.85; CC+CG vs. GG: OR=0.63, 95% CI=0.46-0.86). We also performed the analyses by sample types in IL-6 -174 C/G polymorphism, and significant decreased TB risk was observed in pulmonary tuberculosis group (C allele vs. G allele: OR=0.69, 95% CI=0.52-0.93; CG vs. GG: OR=0.69, 95% CI=0.52-0.91; CC+CG vs. GG: OR=0.71, 95% CI=0.55-0.93), and pulmonary tuberculosis plus extra-pulmonary tuberculosis mixed group (CC vs. GG: OR=0.44, 95% CI=0.22-0.88; CC vs. CG+GG: OR=0.48, 95% CI=0.25-0.94).
CONCLUSIONS
This meta-analysis indicates that the IL-1β -511T/C polymorphism is associated with TB decreased risk in Africans, and IL-6 -174C/G polymorphism in Asians. Further well-designed, large scale studies are required to confirm this conclusion.
背景
关于白细胞介素-1β基因（IL-1β）（+3953C/T，-511T/C）和白细胞介素-6基因（IL-6）（-174G/C）多态性与结核病（TB）易感性之间关联的研究结果并不一致。本荟萃分析的目的是研究这些多态性与结核病风险之间的关系。
方法
我们通过PubMed、Medline、Embase、Web of Science、Elsevier Science Direct和Cochrane图书馆数据库系统检索已发表的关于IL-1β基因和IL-6基因多态性与结核病风险的文献，并从所有文章中提取结果数据。使用Stata 12.0进行统计分析。本研究共纳入15项研究，包括3983例结核病患者和3996例对照。
结果
我们发现IL-6 -174C/G多态性可能与结核病风险降低有关（C vs. G：优势比[OR]=0.77，95%置信区间[CI]=0.64-0.91；CG vs. GG：OR=0.72，95% CI=0.57-0.90；CC+CG vs. GG：OR=0.71，95% CI=0.57-0.88）。在按种族进行的分层分析中，非洲人中IL-1β -511T/C多态性的风险显著降低（C等位基因vs. T等位基因：OR=0.86，95% CI=0.74-0.99；CC vs. TT：OR=0.74，95% CI=0.55-0.99）。此外，IL-6 -174 C/G多态性在亚洲人中也与结核病风险降低有关（C vs. G：OR=0.71，95% CI=0.54-0.93；CG vs. GG：OR=0.61，95% CI=0.44-0.85；CC+CG vs. GG：OR=0.63，95% CI=0.46-0.86）。我们还按IL-6 -174 C/G多态性的样本类型进行了分析，在肺结核组（C等位基因vs. G等位基因：OR=0.69，95% CI=0.52-0.93；CG vs. GG：OR=0.69，95% CI=0.52-0.91；CC+CG vs. GG：OR=0.71，95% CI=0.55-0.93）以及肺结核加肺外结核混合组（CC vs. GG：OR=0.44，95% CI=0.22-0.88；CC vs. CG+GG：OR=0.48，95% CI=0.25-0.94）中观察到结核病风险显著降低。
结论
本荟萃分析表明，IL-1β -511T/C多态性与非洲人结核病风险降低有关，IL-6 -174C/G多态性与亚洲人结核病风险降低有关。需要进一步设计良好的大规模研究来证实这一结论。
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