The Division of Rheumatology, The Department of Internal Medicine, Meram Medical School of Necmettin Erbakan University, Konya, Turkey.
The Division of Nephrology, The Department of Internal Medicine, Konya Health Application and Research Center, University of Health Sciences, Konya, Turkey.
Clin Investig Arterioscler. 2020 Jul-Aug;32(4):135-143. doi: 10.1016/j.arteri.2020.01.002. Epub 2020 Apr 11.
To investigate the frequency of hypogonadism and its relationship to inflammation and carotid intima-media thickness (CIMT) in male patients with predialysis chronic kidney disease (CKD).
A total of 105 patients with CKD, 55 (52.4%) as stage 3, 33 (31.4%) as stage 4 and 17 (16.2%) as stage 5, were enrolled into the study. Total testosterone (TT) and free testosterone (FT), interleukin 6 (IL-6), C-reactive protein (CRP) levels, and CIMT were measured.
According to TT and FT, hypogonadism was detected in 18 (17.1%) and 22 (20.9%) patients, respectively. There was no difference in terms of TT and FT, CIMT, CRP and IL-6 between the stages of CKD. According to TT, the patients with hypogonadism had significantly higher CRP and high-density lipoprotein cholesterol (HDL-cholesterol) levels (p=0.004 and p=0.005, respectively). There was no significant difference in other parameters. According to FT, the patients with hypogonadism had significantly higher CRP (p=0.017), and TT were negatively correlated with body mass index (BMI), waist circumference (WC), hip circumference, and CRP levels. FT was negatively correlated with age, waist circumference, systolic blood pressure, diastolic blood pressure (DBP) and CRP.
The frequency of hypogonadism was found around 17-21% among the patients with CKD. Despite similar IL-6 and CIMT levels, CRP was found to be higher in the patients with hypogonadism. We consider that further studies with larger populations are needed to elucidate the entity.
研究男性透析前慢性肾脏病（CKD）患者性腺功能减退症的发生频率及其与炎症和颈动脉内膜中层厚度（CIMT）的关系。
共纳入 105 例 CKD 患者，其中 3 期 55 例（52.4%），4 期 33 例（31.4%），5 期 17 例（16.2%）。检测总睾酮（TT）、游离睾酮（FT）、白细胞介素 6（IL-6）、C 反应蛋白（CRP）水平和 CIMT。
根据 TT 和 FT，分别检测到 18 例（17.1%）和 22 例（20.9%）性腺功能减退症患者。CKD 各期患者 TT 和 FT、CIMT、CRP 和 IL-6 无差异。根据 TT，性腺功能减退症患者 CRP 和高密度脂蛋白胆固醇（HDL-cholesterol）水平显著升高（p=0.004 和 p=0.005）。其他参数无显著差异。根据 FT，性腺功能减退症患者 CRP 显著升高（p=0.017），TT 与体重指数（BMI）、腰围（WC）、臀围和 CRP 水平呈负相关。FT 与年龄、腰围、收缩压、舒张压（DBP）和 CRP 呈负相关。
CKD 患者性腺功能减退症的发生率约为 17-21%。尽管 IL-6 和 CIMT 水平相似，但性腺功能减退症患者的 CRP 水平较高。我们认为需要进行更大规模的研究来阐明这一问题。
