• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
On Negative Heritability and Negative Estimates of Heritability.论负遗传力和遗传力的负估计。
Genetics. 2020 Jun;215(2):343-357. doi: 10.1534/genetics.120.303161. Epub 2020 Apr 14.
2
Estimating Heritability from Nuclear Family and Pedigree Data.从核心家庭和家系数据估计遗传力。
Methods Mol Biol. 2017;1666:195-210. doi: 10.1007/978-1-4939-7274-6_10.
3
Assumptions and properties of limiting pathway models for analysis of epistasis in complex traits.连锁不平衡模型在复杂性状上位性分析中的假设和性质。
PLoS One. 2013 Jul 30;8(7):e68913. doi: 10.1371/journal.pone.0068913. Print 2013.
4
On the relationship between the heritability and the attributable fraction.论遗传力与归因分数之间的关系。
Hum Genet. 2019 Apr;138(4):425-435. doi: 10.1007/s00439-019-02006-8. Epub 2019 Apr 2.
5
How meaningful are heritability estimates of liability?易感性的遗传力估计值有多大意义？
Hum Genet. 2013 Dec;132(12):1351-60. doi: 10.1007/s00439-013-1334-z. Epub 2013 Jul 19.
6
Quantifying the contribution of dominance deviation effects to complex trait variation in biobank-scale data.量化优势偏差效应对生物库规模数据中复杂性状变异的贡献。
Am J Hum Genet. 2021 May 6;108(5):799-808. doi: 10.1016/j.ajhg.2021.03.018. Epub 2021 Apr 2.
7
Fast and Accurate Construction of Confidence Intervals for Heritability.快速准确地构建遗传力的置信区间
Am J Hum Genet. 2016 Jun 2;98(6):1181-1192. doi: 10.1016/j.ajhg.2016.04.016.
8
The contribution of additive genetic variation to personality variation: heritability of personality.加性基因变异对人格变异的贡献：人格的遗传力。
Proc Biol Sci. 2015 Jan 7;282(1798):20142201. doi: 10.1098/rspb.2014.2201.
9
Relatedness disequilibrium regression estimates heritability without environmental bias.连锁不平衡回归估计遗传率而不受环境偏差影响。
Nat Genet. 2018 Sep;50(9):1304-1310. doi: 10.1038/s41588-018-0178-9. Epub 2018 Aug 13.
10
Genetic evaluation with major genes and polygenic inheritance when some animals are not genotyped using gene content multiple-trait BLUP.当一些动物未使用基因含量多性状BLUP进行基因分型时，利用主基因和多基因遗传进行遗传评估。
Genet Sel Evol. 2015 Nov 17;47:89. doi: 10.1186/s12711-015-0165-x.

引用本文的文献

1
Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability.双胞胎研究提供了2321种血浆蛋白的遗传度估计值，并评估了缺失单核苷酸多态性的遗传度。
J Proteome Res. 2025 Jun 6;24(6):2689-2697. doi: 10.1021/acs.jproteome.4c00971. Epub 2025 May 27.
2
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.超过50种不同细胞类型的三维基因组特征揭示了儿童肥胖症基因组结构的相关见解。
Elife. 2025 Jan 15;13:RP95411. doi: 10.7554/eLife.95411.
3
Allele frequency impacts the cross-ancestry portability of gene expression prediction in lymphoblastoid cell lines.等位基因频率影响淋巴母细胞系中基因表达预测的跨祖先可移植性。
Am J Hum Genet. 2024 Dec 5;111(12):2814-2825. doi: 10.1016/j.ajhg.2024.10.009. Epub 2024 Nov 15.
4
Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories.主要抑郁障碍相关多病共病轨迹簇中的独特遗传和风险因素特征。
Nat Commun. 2024 Aug 21;15(1):7190. doi: 10.1038/s41467-024-51467-7.
5
SumVg: Total Heritability Explained by All Variants in Genome-Wide Association Studies Based on Summary Statistics with Standard Error Estimates.SumVg：基于具有标准误差估计的汇总统计数据的全基因组关联研究中所有变异解释的总遗传力。
Int J Mol Sci. 2024 Jan 22;25(2):1347. doi: 10.3390/ijms25021347.
6
Causal Relationships Between Screen Use, Reading, and Brain Development in Early Adolescents.屏幕使用、阅读与青少年早期大脑发育的因果关系。
Adv Sci (Weinh). 2024 Mar;11(11):e2307540. doi: 10.1002/advs.202307540. Epub 2024 Jan 2.
7
Genetic Mapping for QTL Associated with Seed Nickel and Molybdenum Accumulation in the Soybean 'Forrest' by 'Williams 82' RIL Population.利用‘Williams 82’重组自交系群体对大豆‘Forrest’中与种子镍和钼积累相关的QTL进行遗传定位
Plants (Basel). 2023 Oct 28;12(21):3709. doi: 10.3390/plants12213709.
8
Effects of Genetic Relatedness of Kin Pairs on Univariate ACE Model Performance.亲属对的基因相关性对单变量ACE模型性能的影响。
Twin Res Hum Genet. 2023 Oct 6:1-12. doi: 10.1017/thg.2023.40.
9
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.超过50种不同细胞类型的三维基因组特征揭示了儿童肥胖基因组结构的相关见解。
medRxiv. 2024 Aug 13:2023.08.30.23294092. doi: 10.1101/2023.08.30.23294092.
10
Genetic and environmental influence on resting state networks in young male and female adults: a cartographer mapping study.遗传和环境因素对年轻男性和女性静息态网络的影响：一个图谱绘制研究。
Hum Brain Mapp. 2023 Nov;44(16):5238-5293. doi: 10.1002/hbm.25947. Epub 2022 Dec 20.

本文引用的文献

1
Ultrarare variants drive substantial cis heritability of human gene expression.超罕见变异驱动人类基因表达的大量顺式遗传。
Nat Genet. 2019 Sep;51(9):1349-1355. doi: 10.1038/s41588-019-0487-7. Epub 2019 Sep 2.
2
Statistical properties of simple random-effects models for genetic heritability.用于遗传遗传力的简单随机效应模型的统计特性。
Electron J Stat. 2018;12(1):321-356. doi: 10.1214/17-EJS1386. Epub 2018 Feb 15.
3
A scalable estimator of SNP heritability for biobank-scale data.用于生物库规模数据的 SNP 遗传力可扩展估计器。
Bioinformatics. 2018 Jul 1;34(13):i187-i194. doi: 10.1093/bioinformatics/bty253.
4
A UNIFIED FRAMEWORK FOR VARIANCE COMPONENT ESTIMATION WITH SUMMARY STATISTICS IN GENOME-WIDE ASSOCIATION STUDIES.全基因组关联研究中基于汇总统计量的方差分量估计统一框架
Ann Appl Stat. 2017 Dec;11(4):2027-2051. doi: 10.1214/17-AOAS1052. Epub 2017 Dec 28.
5
Integrative approaches for large-scale transcriptome-wide association studies.大规模全转录组关联研究的综合方法
Nat Genet. 2016 Mar;48(3):245-52. doi: 10.1038/ng.3506. Epub 2016 Feb 8.
6
Limitations of GCTA as a solution to the missing heritability problem.全基因组复杂性状分析（GCTA）作为解决“遗传性缺失”问题方法的局限性。
Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E61-70. doi: 10.1073/pnas.1520109113. Epub 2015 Dec 22.
7
Abundant contribution of short tandem repeats to gene expression variation in humans.短串联重复序列对人类基因表达变异的巨大贡献。
Nat Genet. 2016 Jan;48(1):22-9. doi: 10.1038/ng.3461. Epub 2015 Dec 7.
8
Partitioning heritability by functional annotation using genome-wide association summary statistics.利用全基因组关联研究汇总统计数据，通过功能注释对遗传力进行划分。
Nat Genet. 2015 Nov;47(11):1228-35. doi: 10.1038/ng.3404. Epub 2015 Sep 28.
9
Dominance genetic variation contributes little to the missing heritability for human complex traits.显性遗传变异对人类复杂性状的“缺失遗传力”贡献不大。
Am J Hum Genet. 2015 Mar 5;96(3):377-85. doi: 10.1016/j.ajhg.2015.01.001. Epub 2015 Feb 12.
10
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.LD评分回归在全基因组关联研究中区分混杂因素与多基因性。
Nat Genet. 2015 Mar;47(3):291-5. doi: 10.1038/ng.3211. Epub 2015 Feb 2.

论负遗传力和遗传力的负估计。

On Negative Heritability and Negative Estimates of Heritability.

机构信息

Department of Statistics, University of Oxford, OX1 3TG, United Kingdom

Department of Medicine, University of California, San Francisco, California, 94143

出版信息

Genetics. 2020 Jun;215(2):343-357. doi: 10.1534/genetics.120.303161. Epub 2020 Apr 14.

DOI:10.1534/genetics.120.303161
PMID:32291292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7268991/
Abstract

We consider the problem of interpreting negative maximum likelihood estimates of heritability that sometimes arise from popular statistical models of additive genetic variation. These may result from random noise acting on estimates of genuinely positive heritability, but we argue that they may also arise from misspecification of the standard additive mechanism that is supposed to justify the statistical procedure. Researchers should be open to the possibility that negative heritability estimates could reflect a real physical feature of the biological process from which the data were sampled.

摘要

我们考虑了从加性遗传变异的流行统计模型中有时会出现的负遗传力最大似然估计的解释问题。这些可能是由于对真正正遗传力的估计受到随机噪声的影响，但我们认为，它们也可能是由于标准加性机制的指定不当而导致的，而这种机制应该是统计程序的基础。研究人员应该对这样一种可能性持开放态度，即负遗传力估计可能反映了数据采样的生物过程的真实物理特征。