Kradjan W A, Hudson L D, Harris D M, Emmick G A, Pierson D J
Harborview Medical Center, Seattle, WA.
Drug Intell Clin Pharm. 1988 Oct;22(10):760-3. doi: 10.1177/106002808802201003.
Zindotrine, a new bronchodilator, may be an alternative to theophylline in treating reversible airflow obstruction. Efficacy and cardiovascular effects of a single 300 mg oral dose of zindotrine were compared with placebo in a two-period, double-blind, crossover trial. Twelve subjects with airflow obstruction reversible after isoproterenol and theophylline completed the trial. Improvement in pulmonary function (forced vital capacity [FVC], forced expiratory volume in one second, and forced expiratory flow rate from 25 to 75 percent of FVC) was greater after zindotrine than with placebo. Pulmonary function tests increased 15 percent or more over baseline in 30 minutes after active drug, lasting up to 6 hours. Mild decreases in heart rate and mean blood pressure occurred after both treatments, with changes equal in both treatment groups. Six subjects had mild subjective side effects after zindotrine (headache, dizziness, vertigo, flushing, and heartburn) compared with one report of lightheadedness after placebo. A single dose of zindotrine 300 mg provides effective bronchodilator action with a relatively prolonged response and tolerable side effects.
新型支气管扩张剂辛多曲林在治疗可逆性气流阻塞方面可能是茶碱的替代药物。在一项为期两阶段的双盲交叉试验中，将单次口服300毫克辛多曲林的疗效和心血管效应与安慰剂进行了比较。12名在使用异丙肾上腺素和茶碱后气流阻塞可逆的受试者完成了试验。与安慰剂相比，辛多曲林治疗后肺功能（用力肺活量[FVC]、一秒用力呼气量以及FVC 25%至75%之间的用力呼气流速）改善更明显。使用活性药物后30分钟内，肺功能测试比基线水平提高了15%或更多，持续长达6小时。两种治疗后心率和平均血压均有轻度下降，两个治疗组的变化相同。与安慰剂组1例报告有头晕相比，辛多曲林治疗后有6名受试者出现轻度主观副作用（头痛、头晕、眩晕、脸红和烧心）。单次服用300毫克辛多曲林可提供有效的支气管扩张作用，反应相对持久且副作用可耐受。
