Helmholtz Zentrum München, Institute of Metabolism and Cell Death, Neuherberg, Germany.
National Research Medical University, Laboratory of Experimental Oncology, Moscow, Russia.
J Exp Med. 2020 Jun 1;217(6). doi: 10.1084/jem.20200310.
In this study, Ward et al. (https://doi.org/10.1084/jem.20191689) provide exciting evidence that nucleotide nicotinamide transhydrogenase (NNT), a mitochondrial matrix-located enzyme harnessing the proton gradient to generate NADPH using NADH, markedly contributes to non-small cell lung carcinoma (NSCLC), which is abrogated in the murine C57BL/6J background, a strain known to be deficient in NNT.
在这项研究中，Ward 等人（https://doi.org/10.1084/jem.20191689）提供了令人兴奋的证据，表明核苷酸烟酰胺转氢酶（NNT），一种利用质子梯度利用 NADH 生成 NADPH 的线粒体基质定位酶，对非小细胞肺癌（NSCLC）有显著贡献，而在 C57BL/6J 背景的小鼠中则被消除，C57BL/6J 是一种已知缺乏 NNT 的品系。
