Masuyama Y, Nishio I, Motoki K, Kusuyama Y, Tanaka S
Contrib Nephrol. 1977;6:13-22. doi: 10.1159/000399748.
The role of hypertension in chronic glomerulonephritis was studied in rats with experimental hypertension and nephrotoxic serum nephritis. Nephrotoxic serum nephritis accelerated the hypertensive course of Godblatt's type of experimental hypertension both in the acute and chronic phases. Malignant hypertension was found to be caused in some rats by the nephrotoxic serum injection in the chronic phase of experimental hypertension. Nephrotoxic serum nephritis was more protracted in SHR than in control rats. These results suggest that hypertensive changes might aggravate glomerulitis, and that nephritic processes also facilitate the hypertensive changes.
在患有实验性高血压和肾毒性血清肾炎的大鼠中研究了高血压在慢性肾小球肾炎中的作用。肾毒性血清肾炎在急性和慢性阶段均加速了戈德布拉特型实验性高血压的高血压病程。发现在实验性高血压慢性期给一些大鼠注射肾毒性血清可导致恶性高血压。肾毒性血清肾炎在自发性高血压大鼠（SHR）中比在对照大鼠中持续时间更长。这些结果表明，高血压变化可能会加重肾小球炎症，而肾炎过程也会促进高血压变化。
