潜在的中枢神经系统活性药物。II——4（3H）喹唑啉酮的研究。
Potential CNS active agents. II--Studies of 4(3H)-quinazolinones.
作者信息
Lakhan R, Singh R L
机构信息
Department of Chemistry, Banaras Hindu University, Varanasi, India.
出版信息
Farmaco Sci. 1988 Sep;43(9):745-51.
PMID:3229498
Abstract
Some new 2-carbamoylmethylthio- and 2-(omega-dimethylamino-alkyl)thio-3-aryl-7-chloro-4(3H)-quinazolinones have been prepared from 2-thio-3-aryl-7-chloro-4(3H)-quinazolinones as the key intermediate. Five of the synthetic compounds were screened for their CNS activities on mice and found to be either CNS depressants or stimulants.
摘要
一些新的2-氨甲酰甲基硫代-和2-（ω-二甲基氨基烷基）硫代-3-芳基-7-氯-4（3H）-喹唑啉酮已由2-硫代-3-芳基-7-氯-4（3H）-喹唑啉酮作为关键中间体制备而成。对其中五种合成化合物进行了小鼠中枢神经系统活性筛选，发现它们要么是中枢神经系统抑制剂，要么是兴奋剂。
Zotero 插件