Department of Natural Sciences, Yuzhang Normal University, Nanchang, China.
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Front Immunol. 2020 Mar 31;11:585. doi: 10.3389/fimmu.2020.00585. eCollection 2020.
PKZ is a novel and unique eIF2α protein kinase identified in fish. Although PKZ is most homologous to PKR, particularly in the C-terminal catalytic domain, it contains two N-terminal Z-DNA-binding domains (Zα1 and Zα2) instead of the dsRNA binding domains (dsRBDs) in PKR. As a novel member of eIF2α kinase family, the available data suggest that PKZ has some distinct mechanisms for recognition, binding, and B-Z DNA transition. Functionally, PKZ seems to be activated by the binding of Zα to Z-DNA and participates in innate immune responses. In this review, we summarize the recent progress on fish PKZ.
PKZ 是一种在鱼类中发现的新型独特的 eIF2α 蛋白激酶。尽管 PKZ 与 PKR 最为同源，尤其是在 C 末端催化结构域，但它包含两个 N 端 Z-DNA 结合结构域（Zα1 和 Zα2），而不是 PKR 中的 dsRNA 结合结构域（dsRBDs）。作为 eIF2α 激酶家族的一个新成员，现有数据表明，PKZ 在识别、结合和 B-Z DNA 转变方面具有一些独特的机制。在功能上，PKZ 似乎通过 Zα 与 Z-DNA 的结合而被激活，并参与先天免疫反应。在这篇综述中，我们总结了鱼类 PKZ 的最新进展。
