核碱基参与的天然化学连接：一种鸟嘌呤核苷碱基与 N 端半胱氨酸之间的新型反应，用于寡核苷酸-肽偶联。
Nucleobase-involved native chemical ligation: a novel reaction between an oxanine nucleobase and N-terminal cysteine for oligonucleotide-peptide conjugation.
机构信息
Department of Biotechnology and Bioinformatics, Korea University, Sejong-Ro 2511, Sejong, 30019, Republic of Korea.
出版信息
Chem Commun (Camb). 2020 May 21;56(41):5508-5511. doi: 10.1039/c9cc08808c. Epub 2020 Apr 16.
PMID:32296789
Abstract
In bioconjugation chemistry, achieving a target-specific reaction for a non-modified amino acid is challenging. Here, we report a novel nucleobase-involved native chemical ligation (NbCL) that allows a site-specific oligonucleotide-peptide conjugation via a new S-N acyl transfer reaction between an oxanine nucleobase and N-terminal cysteine.
摘要
在生物共轭化学中，实现非修饰氨基酸的靶向反应具有挑战性。在这里，我们报告了一种新的涉及核苷的天然化学连接（NbCL），它允许通过在噁嗪核苷碱基和 N 端半胱氨酸之间发生新的 S-N 酰基转移反应，实现特定于位置的寡核苷酸-肽连接。
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