阿莫西林治疗后重症肌无力加重：病例系列

Exacerbation of myasthenia gravis after amoxicillin therapy: a case series.

作者信息

Vacchiano Veria, Solli Piergiorgio, Bartolomei Ilaria, Lai Giulia, Liguori Rocco, Salvi Fabrizio

机构信息

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Department of Thoracic Surgery, Maggiore Teaching Hospital, Bologna, Italy.

出版信息

Neurol Sci. 2020 Aug;41(8):2255-2257. doi: 10.1007/s10072-020-04387-5. Epub 2020 Apr 15.

DOI:10.1007/s10072-020-04387-5

PMID:32296986

Abstract

INTRODUCTION

Myasthenia gravis (MG) can be aggravated by several classes of drugs, including antibiotics. Penicillins are considered safe drugs for the management of infectious disease in patients with MG. However, a few cases of MG exacerbations after penicillin treatment have been reported in literature.

CASE REPORTS

We report six patients with MG developing acute worsening of symptoms after amoxicillin or amoxicillin/clavulanate treatment. In most of the cases, symptoms started in a few days after antibiotic administration. In all cases, we observed a worsening of the Myasthenia Gravis Foundation of America (MGFA) clinical classification. Most patients required a therapeutic intervention with dosage increase of the previous therapy or the introduction of new drugs for MG. All patients had a full recovery to baseline neurological conditions within 1-2 months.

CONCLUSIONS

We concluded that patients receiving amoxicillin should be closely monitored for possible acute relapse.

摘要

引言

重症肌无力（MG）可因几类药物而加重，包括抗生素。青霉素被认为是用于MG患者治疗感染性疾病的安全药物。然而，文献中已报道了几例青霉素治疗后MG病情加重的病例。

病例报告

我们报告了6例MG患者在接受阿莫西林或阿莫西林/克拉维酸治疗后症状急性恶化。在大多数病例中，症状在抗生素给药后的几天内开始出现。在所有病例中，我们观察到美国重症肌无力基金会（MGFA）临床分类恶化。大多数患者需要进行治疗干预，增加先前治疗的剂量或引入治疗MG的新药。所有患者在1 - 2个月内完全恢复至基线神经状态。