Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Department of Pediatrics, Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda, MD, 20814, USA.
J Autism Dev Disord. 2020 Dec;50(12):4535-4540. doi: 10.1007/s10803-020-04499-z.
Appendicitis is the most common surgical emergency in children and can lead to significant complications. The aim of our study was to determine whether children with autism spectrum disorders (ASD) are at increased risk for appendicitis and its complications compared to neurotypical (NT) peers. From 2000 to 2013, 292,572 children were included (n = 48,762 ASD). ASD children exhibited an incidence of 8.66 appendicitis cases per 10,000 person-years, P > 0.05. There was an increased risk of perforation in ASD children age 15-17 years-old (OR 2.25; 95% CI 1.15-4.42) as well as an increased odds of sepsis (OR 3.44, 95% CI 1.43-8.27). Providers should display heightened awareness for the risk of complicated appendicitis in children with ASD.
阑尾炎是儿童中最常见的外科急症，可导致严重的并发症。我们的研究目的是确定自闭症谱系障碍（ASD）儿童与神经典型（NT）同龄人相比，阑尾炎及其并发症的风险是否增加。在 2000 年至 2013 年期间，共纳入 292572 名儿童（n=48762 名 ASD）。ASD 儿童的阑尾炎发病率为每 10000 人年 8.66 例，P＞0.05。15-17 岁 ASD 儿童穿孔的风险增加（OR 2.25；95%CI 1.15-4.42），败血症的几率也增加（OR 3.44，95%CI 1.43-8.27）。医务人员应更加注意患有 ASD 的儿童阑尾炎的并发症风险。
