对海洋大环内酯（-）-卡利什海绵内酯的对映选择性形式合成。
Enantioselective formal synthesis of the marine macrolide (-)-callyspongiolide.
机构信息
Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, Barcelona-08028, Spain.
出版信息
Chem Commun (Camb). 2020 May 21;56(41):5536-5539. doi: 10.1039/d0cc01978j.
PMID:32297621
Abstract
A short enantioselective synthesis of the macrocyclic core 19 of callyspongiolide, involving a homocrotylboration of aldehyde 4, a Still-Genari olefination, an esterification with alcohol 17, and a ring-closing metathesis, is reported.
摘要
报道了一种短的对映选择性合成 calyspongiolide 大环核心 19 的方法，涉及醛 4 的同碳丙基硼化、Stil-Genari 烯烃化、与醇 17 的酯化以及环 closing metathesis。
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