Institute of Pharmaceutical Biology and Biotechnology and §Institute of Molecular Medicine, Heinrich-Heine University , 40225 Düsseldorf, Germany.
Org Lett. 2014 Jan 3;16(1):266-9. doi: 10.1021/ol403241v. Epub 2013 Dec 13.
A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated structurally unprecedented diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide showed strong cytotoxicity against human Jurkat J16 T and Ramos B lymphocytes.
一种新型大环内酯类化合物 callyspongiolide 从印度尼西亚采集的海绵 Callyspongia sp. 中分离得到，其结构通过 NMR 和高分辨率质谱（HRMS）谱的综合分析确定。该化合物具有一个氨甲酰基取代的 14 元大环内酯环，带有一个共轭的前所未有的二烯-炔侧链，末端为溴化苯环。Callyspongiolide 对人 Jurkat J16 T 和 Ramos B 淋巴细胞具有很强的细胞毒性。
