急性呼吸窘迫综合征中 p300/CBP 表达增加与白细胞介素-17 及预后相关。

Increased p300/CBP expression in acute respiratory distress syndrome is associated with interleukin-17 and prognosis.

机构信息

Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Department of Respiratory and Critical Care Medicine, The Second Clinical College of North Sichuan Medical College, Nanchong, China.

出版信息

Clin Respir J. 2020 Sep;14(9):791-799. doi: 10.1111/crj.13197. Epub 2020 Jun 24.

DOI:10.1111/crj.13197

PMID:32298537

Abstract

PURPOSE

Transcription co-activator p300/CBP, a histone acetyltransferase, has a central role in tumours, inflammation and neurodegenerative diseases. We investigated the effect of p300/CBP and its association with various IL-17-related indicators and prognosis in patients with acute respiratory distress syndrome (ARDS).

MATERIALS AND METHODS

We enrolled 45 adult ARDS patients who were followed for 28 days and 22 healthy controls. The mRNA expression of p300, CBP, RORγt and Foxp3 and the plasma levels of several cytokines were measured.

RESULT

The mRNA levels of p300, CBP and RORγt, and plasma concentration of IL-17, IL-6, were higher in acute ARDS patients (P < 0.05) compared with controls, and the mean levels of p300, CBP and IL-6 in non-survivors were higher than in survivors (P < 0.05). The expression of p300 was associated with the level of RORγt, IL-17 and disease prognosis.

CONCLUSION

The levels of p300, RORγt mRNA and plasma concentration of IL-6 and IL-17 in acute ARDS patients were increased compared with controls. Increased p300/CBP expression may be an independent risk factor for 28-day mortality in ARDS.

摘要