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[支气管肺病理学患者中的脓肿分枝杆菌复合群代表菌株:患病率、培养及鉴定特点。]

[Mycobacterium abscessus complex representatives in patients with bronchopulmonary pathology: prevalence, peculiarities of cultivation and identification.].

作者信息

Kalimulina K R, Ismatullin D D, Lyamin A V, Kondratenko O V, Kozlov A V, Zhestkov A V

机构信息

Samara State Medical University, 443099, Samara, Russia.

出版信息

Klin Lab Diagn. 2020;65(5):316-320. doi: 10.18821/0869-2084-2020-65-5-316-320.

Abstract

More and more publications appear in the modern literature on the increase in the prevalence of non-tuberculous mycobacteria (NTMs), in particular, representatives of M. chelonae / Mycobacterium abscessus complex (MABSc). The paper presents data on the current classification of M. chelonae / Mycobacterium abscessus complex and its main representatives. The main data on the possible sources and ways of infection of MABSc patients in hospital are presented. The main features of cultivation on various nutrient media and their possible identification using modern methods are also indicated. The main risk factors for the development of mycobacteriosis in patients and the possible clinical picture are described. The prevalence of MABSc representatives in the structure of non-tuberculous mycobacteria isolated from clinical material from 483 patients from the Samara region was assessed for examination for tuberculosis, and the prevalence from 933 patients with cystic fibrosis (CF) from 55 regions of the Russian Federation from 2016 to 2019 was estimated. In total, as a result of the study, 316 NTM strains (65.4%) were isolated and identified in the first group of patients. M.abscessus was isolated and identified 10 strains and 5 strains - M.chelonae, which amounted to 3.2% and 1.6%, respectively, of all NTMs. In general, MABSc representatives were isolated in 3.1% of the examined patients. As a result of a screening study of patients with CF, 14194 microorganism strains from 933 patients were isolated and identified. Altogether M. abscessus was isolated and confirmed from 14 patients of different ages. Thus, the prevalence of MABSc among the examined patients with CF in the Russian Federation was 1.5%.

摘要

现代文献中越来越多的出版物提及非结核分枝杆菌(NTM)患病率的上升,尤其是龟分枝杆菌/脓肿分枝杆菌复合体(MABSc)的代表菌株。本文介绍了龟分枝杆菌/脓肿分枝杆菌复合体及其主要代表菌株的当前分类数据。文中还呈现了医院内MABSc患者可能的感染源和感染途径的主要数据。同时也指出了在各种营养培养基上培养的主要特征以及使用现代方法进行可能鉴定的情况。描述了患者发生分枝杆菌病的主要危险因素以及可能的临床表现。评估了从萨马拉地区483例接受结核病检查的患者临床材料中分离出的非结核分枝杆菌结构中MABSc代表菌株的患病率,并估算了2016年至2019年俄罗斯联邦55个地区933例囊性纤维化(CF)患者中的患病率。研究结果显示,在第一组患者中共分离并鉴定出316株NTM菌株(占65.4%)。分离并鉴定出10株脓肿分枝杆菌和5株龟分枝杆菌,分别占所有NTM的3.2%和1.6%。总体而言,在3.1%的受检患者中分离出了MABSc代表菌株。对CF患者进行筛查研究的结果是,从933例患者中分离并鉴定出14194株微生物菌株。总共从14例不同年龄的患者中分离并确认出脓肿分枝杆菌。因此,俄罗斯联邦受检CF患者中MABSc的患病率为1.5%。

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