Department of Biological Psychiatry, School of Mental Health, Jining Medical University, 272191, Jining, Shandong Province, China; The First Affiliated Hospital/Zhengzhou University, Zhengzhou, China; Biological Psychiatry International Joint Laboratory of Henan, Zhengzhou University, Zhengzhou, China; Henan Psychiatric Transformation Research Key Laboratory, Zhengzhou University, Zhengzhou, 450000, China; Department of Psychiatry and Neuroimaging Centre, Wenzhou Seventh People's Hospital, Wenzhou, 325000, Zhejiang Province, China; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China; MDT Center for Cognitive Impairment and Sleep Disorders, First Hospital of Shanxi Medical University, Taiyuan, 030001, China; Department of Psychiatric-Neuroimging-Genetics and Comorbidity Labotorary (PNGC_Lab), Tianjin Anding Hospital, 300300, Tianjin, China; Canada and China Joint Laboratory of Biological Psychiatry, Xiamen Xianye Hospital, Xiamen, 361000, Fujian Province, China.
Department of Psychiatry and Neuroimaging Centre, Wenzhou Seventh People's Hospital, Wenzhou, 325000, Zhejiang Province, China.
Brain Res Bull. 2020 Jul;160:33-39. doi: 10.1016/j.brainresbull.2020.04.001. Epub 2020 Apr 13.
To explore the unified and disease specific structural features of the brain in patients spanning six mental disorders who experience own-thought auditory verbal hallucinations (OTAVH).
A pilot study was conducted on 25 patients with schizophrenia (FUSCH-OTAVH), 20 patients with major depression disorder (FUMDD-OTAVH), 28 patients with bipolar disorder (FUBD-OTAVH), 22 patients with posttraumatic stress disorder (FUPTSD-OTAVH), 21 patients with anxiety disorder (FUAD-OTAVH), and 27 patients with borderline personality disorder (FUBPD-OTAVH). Twenty-five healthy controls (HCs) were also recruited. Auditory Hallucinations Rating Scale (AHRS) multiple psychometric scales were adopted to assess the clinical features of voxel-based morphometry (VBM), tract-based spatial statistics (TBSS), and multiple regression in all patients. Common and specific brain features of OTAVH among these mental disorders were investigated.
Compared to HCs, GMV aberrant pattern across all the six categories patients with OTAVH decreased in the occipital cortex, left parietal lobe, prefrontal cortex (PFC), and insular cortex (IC). Aberrant patterns in white matter (WM) were detected in the corpus callosum and impairment of the fronto-occipital fasciculus. Structural differences in the brain were observed for each mental disorder versus HCs.
The unified brain aberrant features of OTAVH across six mental disorders were characterized by decreased GMV and WM impairments in some regions and the specific brain features of each disease were also characterized. In conclusion, this study provides evidence for the structural basis of OTAVH and potential avenues for investigating disease specific brain features of OTAVH.
探索跨越六种经历自身思维言语幻听（OTAVH）的精神障碍患者的大脑的统一和特定疾病结构特征。
对 25 例精神分裂症患者（FUSCH-OTAVH）、20 例重性抑郁障碍患者（FUMDD-OTAVH）、28 例双相情感障碍患者（FUBD-OTAVH）、22 例创伤后应激障碍患者（FUPTSD-OTAVH）、21 例焦虑障碍患者（FUAD-OTAVH）和 27 例边缘性人格障碍患者（FUBPD-OTAVH）进行了一项试点研究。还招募了 25 名健康对照者（HCs）。采用听觉幻觉评定量表（AHRS）多项计量学量表评估所有患者的基于体素形态计量学（VBM）、基于束的空间统计学（TBSS）和多元回归的临床特征。研究了这些精神障碍中 OTAVH 的常见和特定大脑特征。
与 HCs 相比，OTAVH 患者所有六个类别的 GMV 异常模式减少，包括枕叶皮层、左侧顶叶皮层、前额叶皮层（PFC）和岛叶皮层（IC）。还在胼胝体和额枕束中检测到白质（WM）异常模式。与 HCs 相比，每个精神障碍都观察到大脑结构的差异。
六种精神障碍的 OTAVH 大脑异常特征是由一些区域 GMV 减少和 WM 损伤引起的，每个疾病的特定大脑特征也得到了描述。总之，本研究为 OTAVH 的结构基础提供了证据，并为研究 OTAVH 的疾病特异性大脑特征提供了潜在途径。
