Department of Basic Nursing Science, School of Nursing, Korea University, Seoul 02841, Republic of Korea.
Exp Biol Med (Maywood). 2020 Jun;245(11):977-982. doi: 10.1177/1535370220920552. Epub 2020 Apr 16.
Excessive dietary fat intake plays important roles in the process of metabolic dysfunction and increases susceptibilities to chronic diseases such as hypertension. Few previous studies, however, have accurately reflected real-world medical conditions. In addition, studies performed to date have not examined detailed sex-differences in cardio-metabolic and cognitive parameters, precluding the development of sex-tailored interventions for patients with metabolic dysfunction who are susceptible to hypertension and cognitive impairment. In this study, using rats with HFD-induced metabolic dysfunction that made them susceptible to hypertension and cognitive impairment, we demonstrate that male rats show greater impairment of acetylcholine-induced vasorelaxation of the carotid artery and systolic blood pressure compared to female rats. These findings may provide a basis for the early detection of carotid artery dysfunction and systolic blood pressure increase, especially in males.
过量的膳食脂肪摄入在代谢功能障碍的过程中起着重要作用，并增加了患高血压等慢性疾病的易感性。然而，之前的研究很少能准确反映现实生活中的医疗状况。此外，迄今为止进行的研究并未检查心脏代谢和认知参数方面的详细性别差异，从而无法为易患高血压和认知障碍的代谢功能障碍患者制定针对性别的干预措施。在这项研究中，我们使用高脂肪饮食（HFD）诱导代谢功能障碍的大鼠，使它们易患高血压和认知障碍，结果表明与雌性大鼠相比，雄性大鼠的颈总动脉乙酰胆碱诱导的血管舒张功能和收缩压受损更为严重。这些发现可能为早期检测颈动脉功能障碍和收缩压升高，特别是在男性中，提供了依据。
