针刺对绝经前超重和肥胖妇女人体测量学和血清代谢参数的影响：一项随机、患者和评估者盲、假针刺对照临床试验。

Effects of acupuncture on anthropometric and serum metabolic parameters in premenopausal overweight and obese women: a randomized, patient- and assessor-blind, sham-controlled clinical trial.

机构信息

Department of Korean Rehabilitation Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Republic of Korea.

出版信息

Acupunct Med. 2021 Feb;39(1):30-40. doi: 10.1177/0964528420912259. Epub 2020 Apr 17.

DOI:10.1177/0964528420912259

PMID:32299241

Abstract

OBJECTIVE

The aim of this study was to examine the effect of acupuncture on obesity-related parameters with regard to metabolomics.

METHODS

This two-arm parallel, patient- and assessor-blind, sham-controlled randomized clinical trial included 120 obese participants. Participants were randomized into two groups. The treatment group received a combined intervention of manual acupuncture (MA) plus electroacupuncture (EA), while the control group received a combination of sham acupuncture interventions consisting of sham MA plus sham EA for 6 weeks. The serum lipid levels were measured as the primary outcome measure and anthropometric parameters and serum metabolic profiles including amino acids and carnitines were measured as secondary outcome measures.

RESULTS

The serum lipid levels and anthropometric measurements did not significantly differ between groups, while body weight, body mass index (BMI), and waist circumference were improved within each group and the level of high-density lipoprotein cholesterol increased over time in the treatment group. There were no significant differences in amino acid levels between groups, while certain carnitine (C2, C4, C6, and l-carnitine) levels were significantly increased ( < 0.05) in the treatment group compared to the control group.

CONCLUSION

In summary, 6 weeks of acupuncture treatment did not affect anthropometric and serum metabolic parameters, with the exception of certain carnitines, when compared to sham acupuncture. The observation of increased carnitine levels in the acupuncture group could result in potential long-term benefits to obese individuals. Additional studies are needed to investigate the long-term effects of acupuncture on lipid metabolism and the underlying mechanism of action.

TRIAL REGISTRATION NUMBER

This study is registered at ClinicalTrials.gov (NCT02066090).

摘要

目的

本研究旨在通过代谢组学研究探讨针灸对肥胖相关参数的影响。

方法

这是一项两臂平行、患者和评估者双盲、假针刺对照的随机临床试验，纳入了 120 名肥胖参与者。参与者被随机分为两组。治疗组接受了手动针刺（MA）加电针（EA）的联合干预，而对照组则接受了假针刺干预的组合，包括假 MA 加假 EA，共进行 6 周。血清脂质水平作为主要观察指标，人体测量参数和血清代谢谱，包括氨基酸和肉碱，作为次要观察指标。