Department of General Surgery, South Campus, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200112, China.
Department of Nursing, South Campus, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200112, China.
BMC Gastroenterol. 2020 Apr 16;20(1):112. doi: 10.1186/s12876-020-01271-6.
Small bowel adenocarcinoma (SBA) is a rare malignancy that primarily occurs in the duodenum. Multiple synchronous SBA is unique rare and difficult to diagnose due to non-specific disease presentation. Protocols to identify multiple synchronous SBA during early disease stages are urgently required.
An elderly man experienced left lower abdominal pain and melena for 3 months. Abdominal CT showed thickening of the multiple segmental small intestinal walls. As the patient had pulmonary tuberculosis simultaneously, he was misdiagnosis as intestinal tuberculosis and received anti-spasm therapy. The treatment delayed radical resection surgery and the patient underwent palliative segmental resection of the jejunum after 4 months due to intestinal obstruction. Resected specimens showed multiple synchronous SBA (five tumors). The patient accepted chemotherapy postoperatively. Six months postoperatively, the patient died of brain metastasis.
We highlight how multiple synchronous SBA is rare and easily misdiagnosed. We should rule out multiple synchronous SBA when diagnosing intestinal diseases (e.g. inflammatory bowel disease, IBS). Intestinal tuberculosis may also be one of the risk factors for multiple synchronous SBA. High-risk patients should be assessed for known tumor makers, and receive gastroscopy, enteroscopy or capsule endoscopy. Doctors should obtain the pathology under endoscopy to the greatest possible degree. For suspected patients, laparotomy should be performed.
小肠腺癌(SBA)是一种罕见的恶性肿瘤,主要发生在十二指肠。由于疾病表现不具有特异性,多个同时发生的 SBA 非常罕见且难以诊断。因此,迫切需要在疾病早期阶段确定多个同时发生的 SBA 的方案。
一名老年男性因左下腹痛和黑便 3 个月就诊。腹部 CT 显示多个节段性小肠壁增厚。由于患者同时患有肺结核,他被误诊为肠结核并接受了抗痉挛治疗。这种治疗延误了根治性切除术,患者在 4 个月后因肠梗阻接受了空肠节段性姑息性切除术。切除标本显示多个同时发生的 SBA(五个肿瘤)。患者术后接受化疗。术后 6 个月,患者因脑转移死亡。
我们强调了多个同时发生的 SBA 是罕见的,且容易误诊。在诊断肠道疾病(如炎症性肠病、IBS)时,我们应该排除多个同时发生的 SBA。肠结核也可能是多个同时发生的 SBA 的一个危险因素之一。高危患者应评估已知的肿瘤标志物,并接受胃镜、结肠镜或胶囊内镜检查。医生应尽可能在内镜下获得病理。对于疑似患者,应进行剖腹探查。