扭转局面：针对 PfCRT 以对抗耐药性疟原虫？
Turning the tide: targeting PfCRT to combat drug-resistant P. falciparum?
机构信息
Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
出版信息
Nat Rev Microbiol. 2020 May;18(5):261-262. doi: 10.1038/s41579-020-0353-8.
Abstract
Resistance to the current first-line antimalarials threatens the control of malaria caused by the protozoan parasite and underscores the urgent need for new drugs with novel modes of action. Here, we present the argument that the parasite’s chloroquine resistance transporter (PfCRT) constitutes a promising target to combat multidrug-resistant malaria.
摘要
抗药性当前一线抗疟药物对原虫寄生虫引起的疟疾控制构成威胁，并凸显出迫切需要具有新型作用模式的新药。在这里，我们提出论点，即寄生虫的氯喹抗性转运蛋白（PfCRT）是对抗多药耐药性疟疾的有希望的靶标。
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