法莫替丁和盐酸雷尼替丁在静脉混合液中的化学稳定性。
Chemical stabilities of famotidine and ranitidine hydrochloride in intravenous admixtures.
作者信息
Das Gupta V, Parasrampuria J, Bethea C
机构信息
Department of Pharmaceutics, University of Houston, TX 77030.
出版信息
J Clin Pharm Ther. 1988 Oct;13(5):329-34. doi: 10.1111/j.1365-2710.1988.tb00201.x.
The chemical stabilities of famotidine and ranitidine hydrochloride solutions in 5% dextrose and 0.9% sodium chloride injections have been studied using high-performance liquid chromatographic methods (HPLC). Both the drugs were stable for at least 15 days (loss in potency of less than 10%) at 25 degrees C and 63 days at 5 degrees C. Both drugs were comparatively less stable in 5% dextrose injection than in 0.9% sodium chloride injection. The loss in the potency of phenol, which is added as a preservative to ranitidine hydrochloride injection, was significant in both the vehicles. However, the addition of preservative in a single dose vial is not considered necessary.
已使用高效液相色谱法（HPLC）研究了法莫替丁和盐酸雷尼替丁溶液在5%葡萄糖注射液和0.9%氯化钠注射液中的化学稳定性。两种药物在25℃下至少稳定15天（效价损失小于10%），在5℃下稳定63天。两种药物在5%葡萄糖注射液中的稳定性相对低于在0.9%氯化钠注射液中的稳定性。作为盐酸雷尼替丁注射液防腐剂添加的苯酚，在两种溶媒中的效价损失均很显著。然而，在单剂量小瓶中添加防腐剂被认为没有必要。
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