College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, United States.
Eleven Bravo LLC, Westport, Wisconson United States, United States.
J Vet Intern Med. 2020 May;34(3):1321-1324. doi: 10.1111/jvim.15765. Epub 2020 Apr 17.
Ponazuril is used for the treatment of equine protozoal myeloencephalitis (EPM). Coadministration of ponazuril with oil could result in higher serum and cerebrospinal fluid (CSF) concentrations of ponazuril.
Coadministration of corn oil will result in higher serum and CSF concentrations of ponazuril than when ponazuril is administered alone.
Ten resident university-owned adult horses of either sex and >2 years of age.
Cohort study. Ponazuril oral paste (5 mg/kg BW; ponazuril treatment group (PON); n = 5), or ponazuril oral paste (5 mg/kg BW; ponazuril and oil treatment group (PONOIL; n = 5) coadministered with 2 oz of corn oil q24h for 21 days. Horses were treated once daily, for 21 days. Blood was collected on days 0, 7, 14, and 21 before dosing. In addition, CSF was collected on days 1, 7, 14, and 21. The concentration of ponazuril was determined in serum and CSF and results compared using repeated measures ANOVA.
Coadministration of ponazuril with 2 oz of corn oil resulted in higher concentrations of ponazuril in serum (at steady state) than that found in horses given ponazuril alone (6.2 ± 0.9 mg/L versus 4.5 ± 1.0 mg/L; P = .004) (mean ± 1 SD). Cerebrospinal fluid concentrations of ponazuril were also greater in horses that received ponazuril and oil (0.213 mg/L ± 0.04 versus 0.162 ± 0.04 mg/L) (P = .03).
Results suggest that coadministration of corn oil with ponazuril might enhance the effectiveness of treatment with ponazuril.
泛昔洛韦用于治疗马属动物原虫性脑脊髓炎（EPM）。泛昔洛韦与油同时给药可导致血清和脑脊液（CSF）中泛昔洛韦浓度升高。
与单独给予泛昔洛韦相比，同时给予玉米油会导致血清和 CSF 中泛昔洛韦浓度升高。
10 匹居住在大学内的成年公马和母马，年龄均>2 岁。
队列研究。泛昔洛韦口服糊剂（5mg/kgBW；泛昔洛韦治疗组（PON），n=5）或泛昔洛韦口服糊剂（5mg/kgBW；泛昔洛韦和油治疗组（PONOIL），n=5），同时每 24 小时给予 2 液盎司玉米油，共 21 天。马每天治疗一次，共 21 天。在给药前的第 0、7、14 和 21 天采集血液。此外，在第 1、7、14 和 21 天采集 CSF。在血清和 CSF 中测定泛昔洛韦的浓度，并使用重复测量方差分析比较结果。
与单独给予泛昔洛韦相比，同时给予 2 液盎司玉米油可使血清（稳态时）中的泛昔洛韦浓度升高（6.2±0.9mg/L 与 4.5±1.0mg/L；P=0.004）（均值±1SD）。接受泛昔洛韦和油的马的 CSF 中泛昔洛韦浓度也更高（0.213mg/L±0.04 与 0.162mg/L±0.04mg/L）（P=0.03）。
结果表明，泛昔洛韦与玉米油同时给药可能会增强泛昔洛韦治疗的效果。
