Department of Chemistry, Faculty of Science, İnönü University, Malatya, Turkey.
Department of Microbiology, Faculty of Pharmacy, İnönü University, Malatya, Turkey.
Arch Pharm (Weinheim). 2020 Jun;353(6):e2000013. doi: 10.1002/ardp.202000013. Epub 2020 Apr 17.
Catechol-containing imidazolium (four) and benzimidazolium chlorides (eight) were synthesized to evaluate their antimicrobial properties. All the compounds were fully characterized using H and C nuclear magnetic resonance, liquid chromatography-mass spectrometry, infrared spectroscopic methods, and elemental analyses. Antimicrobial activities of the compounds were tested against the bacteria Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Enterococcus faecalis, and the fungal strains Candida albicans and Candida glabrata, and promising results were achieved. The two most important benzyl-substituted benzimidazolium chlorides, 3l and 3k, showed comparable activity to vancomycin against MRSA.
合成了含儿茶酚的咪唑鎓（四）和苯并咪唑鎓氯化物（八），以评估它们的抗菌性能。使用 H 和 C 核磁共振、液相色谱-质谱、红外光谱方法和元素分析对所有化合物进行了充分的表征。测试了化合物对细菌大肠杆菌、铜绿假单胞菌、鲍曼不动杆菌、肺炎克雷伯菌、金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌（MRSA）、粪肠球菌和真菌白色念珠菌和光滑念珠菌的抗菌活性，取得了可喜的结果。两个最重要的苄基取代的苯并咪唑鎓氯化物 3l 和 3k 对 MRSA 的活性与万古霉素相当。
