Royal Prince Alfred Hospital and Charles Perkins Centre, University of Sydney, Sydney, Australia.
Seoul National University, Seoul, South Korea.
Transplantation. 2020 Apr;104(4S1 Suppl 1):S11-S103. doi: 10.1097/TP.0000000000003136.
The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation is intended to assist health care professionals worldwide who evaluate and manage potential candidates for deceased or living donor kidney transplantation. This guideline addresses general candidacy issues such as access to transplantation, patient demographic and health status factors, and immunological and psychosocial assessment. The roles of various risk factors and comorbid conditions governing an individual's suitability for transplantation such as adherence, tobacco use, diabetes, obesity, perioperative issues, causes of kidney failure, infections, malignancy, pulmonary disease, cardiac and peripheral arterial disease, neurologic disease, gastrointestinal and liver disease, hematologic disease, and bone and mineral disorder are also addressed. This guideline provides recommendations for evaluation of individual aspects of a candidate's profile such that each risk factor and comorbidity are considered separately. The goal is to assist the clinical team to assimilate all data relevant to an individual, consider this within their local health context, and make an overall judgment on candidacy for transplantation. The guideline development process followed the Grades of Recommendation Assessment, Development, and Evaluation (GRADE) approach. Guideline recommendations are primarily based on systematic reviews of relevant studies and our assessment of the quality of that evidence, and the strengths of recommendations are provided. Limitations of the evidence are discussed with differences from previous guidelines noted and suggestions for future research are also provided.
2020 年肾脏病：改善全球预后（KDIGO）关于评估和管理肾移植候选人的临床实践指南旨在协助全球评估和管理已故或活体供肾移植潜在候选人的医疗保健专业人员。本指南涉及一般候选资格问题，如获得移植的机会、患者人口统计学和健康状况因素以及免疫和社会心理评估。还涉及各种风险因素和合并症对个体移植适宜性的影响，例如依从性、吸烟、糖尿病、肥胖、围手术期问题、肾衰竭原因、感染、恶性肿瘤、肺部疾病、心脏和外周动脉疾病、神经疾病、胃肠道和肝脏疾病、血液疾病以及骨骼和矿物质疾病。本指南提供了评估候选人个人资料各个方面的建议，以便分别考虑每个风险因素和合并症。目标是帮助临床团队整合与个体相关的所有数据，在当地卫生环境下考虑这些数据，并对移植候选资格做出总体判断。指南制定过程遵循推荐评估、制定和评估（GRADE）方法。指南建议主要基于对相关研究的系统评价以及我们对该证据质量的评估，同时提供了建议的强度。讨论了证据的局限性，并指出了与以前指南的差异，还提供了未来研究的建议。
