University of Debrecen Faculty of Medicine, Department of Obstetrics and Gynecology, Debrecen, Hungary.
Eastern Virginia Medical School, Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, Norfolk, VA.
Menopause. 2020 Jul;27(7):776-779. doi: 10.1097/GME.0000000000001536.
This study aimed to investigate the correlation between cervicovaginal fluid zinc levels and participants' menopausal status and the presence of vulvovaginal symptoms of genitourinary syndrome of menopause.
Women included in the study underwent a pelvic examination, collection of vaginal cytology, and cervicovaginal lavage was performed in a standardized fashion. The cervicovaginal lavage zinc content was determined. The vaginal health index was calculated, and the visual analog scale was obtained based on the participant's burning, itching, vaginal pain, dyspareunia, dryness, and dysuria.
One hundred twenty women participated in the study. Eighty-two participants were menopausal. The mean vaginal health index was 15 ± 6, while the total visual analog scale score was 14 ± 14. We found significant differences between cervicovaginal lavage zinc level and age group, menopausal status, presence of vaginal dryness, and vaginal atrophy. We also found a moderate positive correlation between Vaginal Maturation Value and cervicovaginal lavage zinc levels (r = 0.495, P value < 0.01) in the correlation analysis. However, in the multivariate regression model, including all significant factors, only vaginal atrophy remained significant.
We found a significant association between vaginal atrophy (vaginal maturation value < 50) and cervicovaginal lavage zinc levels. Zinc levels of cervicovaginal lavage could be used as a new marker of vaginal atrophy. : Video Summary:http://links.lww.com/MENO/A575.
本研究旨在探讨阴道分泌物锌水平与参与者绝经状态及女性绝经后生殖泌尿系统综合征（genitourinary syndrome of menopause，GSM）相关外阴阴道症状之间的相关性。
研究纳入的女性患者均接受盆腔检查、阴道细胞学采集和标准化阴道灌洗。检测阴道灌洗液中的锌含量，计算阴道健康指数（vaginal health index，VHI），并采用视觉模拟量表（visual analog scale，VAS）评估患者的烧灼感、瘙痒感、阴道疼痛、性交困难、阴道干燥和排尿困难等症状。
本研究共纳入 120 名女性患者，其中 82 名为绝经女性。阴道健康指数的平均值为 15±6，VAS 总评分的平均值为 14±14。我们发现阴道灌洗液锌水平与年龄组、绝经状态、阴道干燥和阴道萎缩之间存在显著差异。相关性分析显示，阴道成熟度值与阴道灌洗液锌水平之间存在中度正相关（r=0.495，P 值<0.01）。然而，在包括所有显著因素的多元回归模型中，只有阴道萎缩仍然具有统计学意义。
我们发现阴道萎缩（阴道成熟度值<50）与阴道灌洗液锌水平之间存在显著关联。阴道灌洗液锌水平可作为阴道萎缩的一个新标志物。
