Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Mol Cell. 2020 Apr 16;78(2):193-194. doi: 10.1016/j.molcel.2020.03.029.
Heterochromatin protein 1 (HP1) has been proposed to drive heterochromatin formation by liquid-liquid phase separation. In this issue of Molecular Cell, however, Erdel et al. establish that heterochromatin can adopt digital compaction states that are independent of HP1 phase separation.
异染色质蛋白 1(HP1)被认为可以通过液-液相分离驱动异染色质的形成。然而,在本期《分子细胞》中,Erdel 等人证明异染色质可以采用独立于 HP1 相分离的数字紧缩状态。