药物超敏反应的快车道：临床医生应该了解的表型、内型和生物标志物。
Drug hypersensitivity in the fast lane: What clinicians should know about phenotypes, endotypes, and biomarkers.
机构信息
Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Divison of Allergy, Marqués de Valdecilla University Hospital-Instituto de Investigacion Marques de Valdecilla (IDIVAL), Santander, Spain.
出版信息
Ann Allergy Asthma Immunol. 2020 Jun;124(6):566-572. doi: 10.1016/j.anai.2020.04.005. Epub 2020 Apr 15.
OBJECTIVE
To review novel concepts in drug hypersensitivity and the management of immediate hypersensitivity reactions.
DATA SOURCES
English language literature on MEDLINE and Embase surrounding drug hypersensitivity and desensitization.
STUDY SELECTIONS
References were selected based on relevance, date of publication, and originality.
RESULTS
There are numerous citations looking at categorizing drug reactions, pathogenesis, biomarkers, and desensitization. Current understanding supports the use of a phenotype-endotype-biomarker model for categorizing immediate hypersensitivity reactions. Drug desensitization is a powerful therapeutic strategy that enables temporary induction of tolerance to medications that triggered immediate reactions.
CONCLUSION
Immediate hypersensitivity reactions are diverse in presentation and pathogenesis. Drug desensitization is an effective intervention with sufficient evidence to support its more widespread availability.
目的
综述药物过敏反应的新概念和即刻过敏反应的管理。
资料来源
围绕药物过敏反应和脱敏治疗的 MEDLINE 和 Embase 上的英文文献。
研究选择
根据相关性、出版日期和原创性选择参考文献。
结果
有许多研究探讨了药物反应的分类、发病机制、生物标志物和脱敏治疗。目前的认识支持使用表型-表型-生物标志物模型来对即刻过敏反应进行分类。药物脱敏是一种强大的治疗策略，可暂时诱导对引发即刻反应的药物的耐受性。
结论
即刻过敏反应在表现和发病机制上存在多样性。药物脱敏是一种有效的干预措施，有足够的证据支持其更广泛的应用。
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