撒哈拉以南非洲地区类风湿性关节炎的流行病学：系统评价和荟萃分析方案。
Epidemiology of rheumatoid arthritis in sub-Saharan Africa: a systematic review and meta-analysis protocol.
机构信息
Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Psychiatry internship program, University of Bourgogne, 21000, Dijon, France.
出版信息
Syst Rev. 2020 Apr 17;9(1):81. doi: 10.1186/s13643-020-01342-5.
BACKGROUND
So far, only one meta-analysis has estimated the prevalence of rheumatoid arthritis (RA) in Africa. Out of 10 studies included in that meta-analysis, nine came from sub-Saharan African countries and had been published between 1968 and 1988. We will conduct a new systematic review and meta-analysis to update their estimates and provide more consistent prevalence data on RA in sub-Saharan Africa.
METHODS
We will comprehensively search electronic databases to select observational studies addressing RA in sub-Saharan Africa and published as from 1 January 2000: PubMed, EMBASE, African Journals Online, Web of Science, and Global Index Medicus. Summary estimates will be derived through random-effects meta-analysis whenever possible. Alternatively, estimates will be reported through narrative synthesis when the random-effects meta-analysis will be impossible. The risk of bias will be assessed using standard methods.
DISCUSSION
This systematic review and meta-analysis shall quantify the magnitude of RA morbidity and mortality in sub-Saharan Africa. Results from this review will be disseminated in peer-reviewed journals, conferences and on social media platforms.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO CRD42020153483.
背景
迄今为止，仅有一项荟萃分析估算了非洲类风湿关节炎（RA）的患病率。该荟萃分析纳入的 10 项研究中，有 9 项来自撒哈拉以南非洲国家，发表于 1968 年至 1988 年。我们将进行一项新的系统评价和荟萃分析，以更新其估计结果，并提供撒哈拉以南非洲 RA 的更一致的患病率数据。
方法
我们将全面检索电子数据库，以选择自 2000 年 1 月 1 日起发表的关于撒哈拉以南非洲 RA 的观察性研究：PubMed、EMBASE、African Journals Online、Web of Science 和 Global Index Medicus。只要有可能，我们将通过随机效应荟萃分析得出汇总估计值。否则，如果无法进行随机效应荟萃分析，我们将通过叙述性综合报告估计值。我们将使用标准方法评估偏倚风险。
讨论
本系统评价和荟萃分析将定量评估撒哈拉以南非洲 RA 的发病率和死亡率。本综述的结果将在同行评议期刊、会议和社交媒体平台上发表。
系统评价注册
PROSPERO CRD42020153483。
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