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[小儿睾丸旁横纹肌肉瘤的腹膜后淋巴结评估]

[Retroperitoneal lymph node assessment in pediatric paratesticular rhabdomyosarcoma].

作者信息

Guérin Florent, Martelli Hélène

机构信息

Hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, université Paris-Saclay, chirurgie pédiatrique, 78, rue du Général-Leclerc, 94270 Le Kremlin-Bicêtre, France.

Hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, université Paris-Saclay, chirurgie pédiatrique, 78, rue du Général-Leclerc, 94270 Le Kremlin-Bicêtre, France.

出版信息

Bull Cancer. 2020 Jun;107(6):666-671. doi: 10.1016/j.bulcan.2020.03.007. Epub 2020 Apr 14.

Abstract

Paratesticular Rhabdomyosarcoma accounts for 7 to 11% of pediatric rhabdomyosarcomas. Children older than 10 years have a worse event-free survival (69 to 80% vs. 87 to 92%) than children younger than 10 years. In this location, the relapses are essentially in the retroperitoneal lymph nodes and are often fatal. In European protocols, the assessment of the retroperitoneal lymph nodes at diagnosis is made by imaging whereas it is performed by retroperitoneal lymph node dissection in the American protocols. This method has been proved to improve event-free survival in the group of patient older than 10 years with a tumour bigger than 5cm. In the next European protocol, when nodes will be enlarged a surgical biopsy will be performed, this will be irrespective of age or size, and when no nodes will be enlarged in patients older than 10 years, retroperitoneal lymph node assessment will be performed. Other techniques of lymph nodes assessment will be tested like sentinel node biopsies or PET-scan.

摘要

睾丸旁横纹肌肉瘤占儿童横纹肌肉瘤的7%至11%。10岁以上儿童的无事件生存率(69%至80%,而10岁以下儿童为87%至92%)低于10岁以下儿童。在这个部位,复发主要发生在腹膜后淋巴结,且往往是致命的。在欧洲的方案中,诊断时对腹膜后淋巴结的评估通过影像学进行,而在美国的方案中则通过腹膜后淋巴结清扫术进行。已证明该方法可提高肿瘤大于5cm的10岁以上患者组的无事件生存率。在下一个欧洲方案中,当淋巴结肿大时将进行手术活检,这与年龄或大小无关,而当10岁以上患者的淋巴结未肿大时,将进行腹膜后淋巴结评估。其他淋巴结评估技术,如前哨淋巴结活检或PET扫描,将进行测试。

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