Department of Biomedical Genetics and Wilmot Cancer Institute, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, NY 14642, USA.
Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Trends Cell Biol. 2020 Jun;30(6):440-451. doi: 10.1016/j.tcb.2020.03.002. Epub 2020 Apr 14.
Reactive oxygen species (ROS) play important roles in tissue homeostasis, cellular signaling, differentiation, and survival. In this review, we discuss the types ofROS, their impact on cellular processes, and their pro- and antitumorigenic effects. Further, we discuss recent advances in our understanding of both endogenous and exogenous antioxidants in tumorigenic processes. Finally, wediscuss how aberrant activation of antioxidant programs by the transcription factor NFE2-related factor 2 (NRF2) influences tumorigenesis and metastasis, and where the current gaps in our knowledge remain.
活性氧（ROS）在组织动态平衡、细胞信号转导、分化和存活中发挥着重要作用。在这篇综述中，我们讨论了 ROS 的类型、它们对细胞过程的影响，以及它们的促肿瘤和抗肿瘤作用。此外，我们还讨论了我们在肿瘤发生过程中对内源性和外源性抗氧化剂的理解的最新进展。最后，我们讨论了转录因子 NFE2 相关因子 2（NRF2）异常激活抗氧化程序如何影响肿瘤发生和转移，以及我们目前的知识空白在哪里。
