Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
NIHR Biomedical Research Centre, Oxford, UK.
BMJ Open. 2020 Apr 16;10(4):e030609. doi: 10.1136/bmjopen-2019-030609.
The purpose of this study was to analyse the rate of knee arthroplasty in the population of patients with a history of arthroscopic chondroplasty of the knee, in England, over 10 years, with comparison to general population data for patients without a history of chondroplasty.
Retrospective cohort study.
English Hospital Episode Statistics (HES) data.
Patients undergoing arthroscopic chondroplasty in England between 2007/2008 and 2016/2017 were identified. Patients undergoing previous arthroscopic knee surgery or simultaneous cruciate ligament reconstruction or microfracture in the same knee were excluded.
Patients subsequently undergoing a knee arthroplasty in the same knee were identified and mortality-adjusted survival analysis was performed (survival without undergoing knee arthroplasty). A Cox proportional hazards model was used to identify factors associated with knee arthroplasty. Relative risk of knee arthroplasty (total or partial) in comparison to the general population was determined.
Through 2007 to 2017, 157 730 eligible chondroplasty patients were identified. Within 1 year, 5.91% (7984/135 197; 95% CI 5.78 to 6.03) underwent knee arthroplasty and 14.22% (8145/57 267; 95% CI 13.94 to 14.51) within 5 years. Patients aged over 30 years with a history of chondroplasty were 17.32 times (risk ratio; 95% CI 16.81 to 17.84) more likely to undergo arthroplasty than the general population without a history of chondroplasty.
Patients with cartilage lesions of the knee, treated with arthroscopic chondroplasty, are at greater risk of subsequent knee arthroplasty than the general population and for a proportion of patients, there is insufficient benefit to prevent the need for knee arthroplasty within 1 to 5 years. These important new data will inform patients of the anticipated outcomes following this procedure. The risk in comparison to non-operative treatment remains unknown and there is an urgent need for a randomised clinical trial in this population.
本研究旨在分析 10 多年来在英国接受膝关节镜下软骨成形术的患者人群中膝关节置换术的比例,并与无软骨成形术史的一般人群数据进行比较。
回顾性队列研究。
英国医院病例统计(HES)数据。
确定了 2007/2008 年至 2016/2017 年期间在英国接受膝关节镜下软骨成形术的患者。排除了既往膝关节镜手术或同时行同侧膝关节交叉韧带重建或微骨折的患者。
确定了随后在同一膝关节行膝关节置换术的患者,并进行了死亡率调整的生存分析(未行膝关节置换术的生存情况)。使用 Cox 比例风险模型来确定与膝关节置换术相关的因素。确定了与一般人群相比膝关节置换术(全膝关节或部分膝关节)的相对风险。
通过 2007 年至 2017 年,共确定了 157730 例符合条件的软骨成形术患者。在 1 年内,5.91%(7984/135197;95%CI 5.78%至 6.03%)行膝关节置换术,5 年内 14.22%(8145/57267;95%CI 13.94%至 14.51%)行膝关节置换术。有软骨成形术史的 30 岁以上患者行关节成形术的可能性是无软骨成形术史的一般人群的 17.32 倍(风险比;95%CI 16.81%至 17.84%)。
膝关节软骨病变患者接受膝关节镜下软骨成形术治疗后,行膝关节置换术的风险高于一般人群,对于一部分患者,在 1 至 5 年内,该手术并不能提供足够的益处,以预防膝关节置换术的需要。这些新的重要数据将为接受该手术的患者提供预期结果。与非手术治疗相比,风险仍然未知,因此迫切需要在该人群中进行随机临床试验。