BK 通道促进神经肌肉传递。

BK channels promote neuromuscular transmission.

出版信息

J Gen Physiol. 2020 May 4;152(5). doi: 10.1085/jgp.202012616.

DOI:10.1085/jgp.202012616

PMID:32303753

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7201887/

Abstract

Mice lacking BK channels are weak because of reduced vesicle release at neuromuscular junctions.

摘要

缺乏 BK 通道的小鼠由于神经肌肉接头处囊泡释放减少而变得虚弱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f182/7201887/02d80223a6d2/JGP_202012616_Fig1.jpg

相似文献

BK channels promote neuromuscular transmission.BK 通道促进神经肌肉传递。

J Gen Physiol. 2020 May 4;152(5). doi: 10.1085/jgp.202012616.

Depressed neuromuscular transmission causes weakness in mice lacking BK potassium channels.BK 钾通道缺失的小鼠神经肌肉传递受阻导致肌无力。

J Gen Physiol. 2020 May 4;152(5). doi: 10.1085/jgp.201912526.

BK channels and a cGMP-dependent protein kinase (PKG) function through independent mechanisms to regulate the tolerance of synaptic transmission to acute oxidative stress at the Drosophila larval neuromuscular junction.BK通道和一种环磷酸鸟苷依赖性蛋白激酶（PKG）通过独立机制发挥作用，以调节果蝇幼虫神经肌肉接头处突触传递对急性氧化应激的耐受性。

J Neurogenet. 2018 Sep;32(3):246-255. doi: 10.1080/01677063.2018.1500571.

Distinct roles of Drosophila cacophony and Dmca1D Ca(2+) channels in synaptic homeostasis: genetic interactions with slowpoke Ca(2+) -activated BK channels in presynaptic excitability and postsynaptic response.果蝇 cacophony 和 Dmca1D Ca(2+) 通道在突触稳态中的独特作用：与慢激活性 BK Ca(2+) 通道在突触前兴奋性和突触后反应中的遗传相互作用。

Dev Neurobiol. 2014 Jan;74(1):1-15. doi: 10.1002/dneu.22120. Epub 2013 Oct 7.

Archaerhodopsin voltage imaging: synaptic calcium and BK channels stabilize action potential repolarization at the Drosophila neuromuscular junction.古菌视紫红质电压成像：突触钙通道和大电导钙激活钾通道稳定果蝇神经肌肉接头处动作电位的复极化过程。

J Neurosci. 2014 Oct 29;34(44):14517-25. doi: 10.1523/JNEUROSCI.2203-14.2014.

Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction.成年、新生及P/Q型缺乏的神经肌肉接头处的钙离子通道与突触传递

Ann N Y Acad Sci. 2003 Sep;998:11-7. doi: 10.1196/annals.1254.003.

Activation of large-conductance Ca(2+)-activated K(+) channels depresses basal synaptic transmission in the hippocampal CA1 area in APP (swe/ind) TgCRND8 mice.大电导钙激活钾通道的激活可降低 APP（swe/ind）TgCRND8 小鼠海马 CA1 区的基础突触传递。

Neurobiol Aging. 2010 Apr;31(4):591-604. doi: 10.1016/j.neurobiolaging.2008.05.012. Epub 2008 Jun 10.

Regulation of synaptic transmission at the Caenorhabditis elegans M4 neuromuscular junction by an antagonistic relationship between two calcium channels.两个钙通道之间的拮抗关系对秀丽隐杆线虫M4神经肌肉接头处突触传递的调节

G3 (Bethesda). 2014 Nov 4;4(12):2535-43. doi: 10.1534/g3.114.014308.

Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release.谷氨酸能海马终末中的突触前钙离子激活钾通道及其在动作电位复极化和递质释放调节中的作用。

J Neurosci. 2001 Dec 15;21(24):9585-97. doi: 10.1523/JNEUROSCI.21-24-09585.2001.

Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleus.突触前BK通道调节乙醇诱导的大鼠中央杏仁核中GABA能传递的增强。

J Neurosci. 2014 Oct 8;34(41):13714-24. doi: 10.1523/JNEUROSCI.5284-13.2014.

本文引用的文献

Iberiotoxin-induced block of Ca2+-activated K+ channels induces dihydropyridine sensitivity of ACh release from mammalian motor nerve terminals.埃博毒素诱导的钙激活钾通道阻断可诱导哺乳动物运动神经末梢乙酰胆碱释放对二氢吡啶敏感。

J Pharmacol Exp Ther. 2003 May;305(2):646-52. doi: 10.1124/jpet.102.046102. Epub 2003 Jan 24.

Reduced transmitter release conferred by mutations in the slowpoke-encoded Ca2(+)-activated K+ channel gene of Drosophila.果蝇慢poke编码的钙激活钾通道基因突变导致递质释放减少。

Invert Neurosci. 1996 Jun;2(1):51-60. doi: 10.1007/BF02336660.

Modulation of acetylcholine release at mouse neuromuscular junctions by interaction of three homologous scorpion toxins with K+ channels.三种同源蝎毒素与钾离子通道相互作用对小鼠神经肌肉接头处乙酰胆碱释放的调节作用。

Br J Pharmacol. 1995 Apr;114(7):1502-6. doi: 10.1111/j.1476-5381.1995.tb13377.x.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

BK 通道促进神经肌肉传递。

BK channels promote neuromuscular transmission.

出版信息

相似文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

本文引用的文献