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BK 通道促进神经肌肉传递。

BK channels promote neuromuscular transmission.

出版信息

J Gen Physiol. 2020 May 4;152(5). doi: 10.1085/jgp.202012616.

DOI:10.1085/jgp.202012616
PMID:32303753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7201887/
Abstract

Mice lacking BK channels are weak because of reduced vesicle release at neuromuscular junctions.

摘要

缺乏 BK 通道的小鼠由于神经肌肉接头处囊泡释放减少而变得虚弱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f182/7201887/02d80223a6d2/JGP_202012616_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f182/7201887/02d80223a6d2/JGP_202012616_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f182/7201887/02d80223a6d2/JGP_202012616_Fig1.jpg

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本文引用的文献

1
Iberiotoxin-induced block of Ca2+-activated K+ channels induces dihydropyridine sensitivity of ACh release from mammalian motor nerve terminals.埃博毒素诱导的钙激活钾通道阻断可诱导哺乳动物运动神经末梢乙酰胆碱释放对二氢吡啶敏感。
J Pharmacol Exp Ther. 2003 May;305(2):646-52. doi: 10.1124/jpet.102.046102. Epub 2003 Jan 24.
2
Reduced transmitter release conferred by mutations in the slowpoke-encoded Ca2(+)-activated K+ channel gene of Drosophila.果蝇慢poke编码的钙激活钾通道基因突变导致递质释放减少。
Invert Neurosci. 1996 Jun;2(1):51-60. doi: 10.1007/BF02336660.
3
Modulation of acetylcholine release at mouse neuromuscular junctions by interaction of three homologous scorpion toxins with K+ channels.
三种同源蝎毒素与钾离子通道相互作用对小鼠神经肌肉接头处乙酰胆碱释放的调节作用。
Br J Pharmacol. 1995 Apr;114(7):1502-6. doi: 10.1111/j.1476-5381.1995.tb13377.x.