Gruhl H, Gilek U
Institut für Laboratoriumsmedizin, Zentralklinikum Augsburg.
J Clin Chem Clin Biochem. 1988 Oct;26(10):627-33.
Cadmium concentrations in liver and kidney were determined in 68 deceased patients (41 male, 27 female) from the Augsburg area. The following concentrations were found: liver 2.2-77.3 (median 16.0) nmol/g dry weight; renal cortex 87.2-2120.0 (median 315.4) nmol/g dry weight; renal medulla 34.7-913.7 (median 186.4) nmol/g dry weight. On average, the values for the renal medullas were 0.56 times the values for the renal cortex. Females showed lower values in liver, renal cortex and renal medulla than males. The total bodily burden with cadmium was determined to be 13.2-303.9 (median 51.6) mumol. A moderate, but significant correlation was found between the cadmium concentrations in the liver and the kidney (rs = 0.3), a stronger correlation between the concentrations in the renal cortex and renal medulla (rs = 0.6). The problematic conversion of the results obtained with wet samples into values for dry samples is discussed, as well as the possible influence of different diseases of the liver and/or the kidney on the concentrations found.
对奥格斯堡地区68名已故患者(41名男性,27名女性)的肝脏和肾脏中的镉浓度进行了测定。结果如下:肝脏中镉浓度为2.2 - 77.3(中位数16.0)纳摩尔/克干重;肾皮质中镉浓度为87.2 - 2120.0(中位数315.4)纳摩尔/克干重;肾髓质中镉浓度为34.7 - 913.7(中位数186.4)纳摩尔/克干重。平均而言,肾髓质中的数值是肾皮质中数值的0.56倍。女性在肝脏、肾皮质和肾髓质中的数值低于男性。体内镉的总负荷量为13.2 - 303.9(中位数51.6)微摩尔。肝脏和肾脏中的镉浓度之间存在中等程度但显著的相关性(rs = 0.3),肾皮质和肾髓质中的浓度之间存在更强的相关性(rs = 0.6)。文中讨论了将湿样本所得结果转换为干样本数值时存在的问题,以及肝脏和/或肾脏的不同疾病对所测浓度可能产生的影响。