Division of Orthodontics, University Clinics of Dental Medicine, University of Geneva, Geneva, Switzerland.
Division of Pediatric Surgery, Department of Pediatrics, University Center of Pediatric Surgery of Western Switzerland, Geneva University Hospitals, Geneva, Switzerland.
Orthod Craniofac Res. 2020 Nov;23(4):398-403. doi: 10.1111/ocr.12380. Epub 2020 May 7.
To use morphometric methods to investigate the size and shape of the sella turcica in children with unilateral cleft lip and palate (UCLP).
Fifty-six healthy children with non-syndromic UCLP, from a major paediatric teaching hospital, with lateral cephalograms taken prior to alveolar bone grafting, were compared with an age- and sex-matched control group of healthy children without orofacial clefts, with lateral cephalograms taken prior to orthodontic treatment.
In this cross-sectional study, conventional measurements were performed on the sella turcica to measure width, height and area on lateral cephalograms. Sella shape was also analysed using 11 points defining the sella turcica contours, using geometric morphometrics. Procrustes superimposition was used to register all sella contour tracings to calculate average sella shape. Principal component analysis was applied to the residuals of the point coordinates, and principal components (PCs) of shape were extracted.
Statistically significant differences between the UCLP and control groups were found for sella posterior height, midpoint height, maximum height and area, where all of these were smaller in children with UCLP. Principal component analysis revealed that the first two PCs accounted for 84.7% of total shape variance. There was a statistically significant difference in sella shape between children with UCLP and control children.
In children with UCLP, the sella turcica is shorter and with a smaller surface area when compared to matched non-cleft children. Moreover, sella turcica shape, when disregarding size, seems to differ to that of non-cleft children.
使用形态计量学方法研究单侧唇腭裂（UCLP）儿童蝶鞍的大小和形状。
56 例来自主要儿科教学医院的非综合征性 UCLP 健康儿童，在牙槽骨植骨前拍摄侧位头颅侧位片，与年龄和性别匹配的无口面裂健康儿童对照组进行比较，对照组在正畸治疗前拍摄侧位头颅侧位片。
在这项横断面研究中，在侧位头颅侧位片上对蝶鞍进行常规测量，以测量宽度、高度和面积。使用几何形态计量学，还通过定义蝶鞍轮廓的 11 个点来分析蝶鞍的形状。使用 Procrustes 叠加法对所有蝶鞍轮廓轨迹进行注册，以计算平均蝶鞍形状。对坐标残差应用主成分分析，并提取形状的主成分（PC）。
UCLP 组和对照组之间在蝶鞍后高、中点高、最大高和面积方面存在统计学显著差异，UCLP 组的这些值均较小。主成分分析显示，前两个 PC 占总形状方差的 84.7%。UCLP 儿童与对照组儿童的蝶鞍形状存在统计学显著差异。
与匹配的非裂隙儿童相比，UCLP 儿童的蝶鞍更短，表面积更小。此外，在不考虑大小的情况下，蝶鞍的形状似乎与非裂隙儿童不同。
