Wang Chenglin, Gao Jiguo, Li Min, Qi Hehe, Zhao Teng, Zhang Bing, Zhou Chunkui, Fang Shaokuan
Neuroscience Center, Department of Neurology, the First Hospital of Jilin University, Jilin University, Changchun, China.
Department of Neurology, Huaihe Hospital of Henan University, Kaifeng, Henan Province, China.
Neuro Endocrinol Lett. 2019 Dec;40(7-8):333-341.
Cerebral small vessel diseases (CSVDs) are common causes of cognitive impairments and mood disorders. In recent years, event-related potential P300 has received increasing attention as a biomarker of cognitive impairments or mood disorders. Previous studies on P300 mainly focused on anxiety, depression or cognitive impairments, and few results have been reported on P300 in CSVD patients. The present study aimed to explore the relationship between neuropsychological test scores and P300 in patients with CSVDs.
The clinical data of 52 patients with CSVDs admitted to the Neurology ward of the First Hospital of Jilin University from June 2016 to October 2017 were collected. All patients who met the inclusion criteria were assessed by both cognitive tests and mood scales within 1 week after enrollment, followed by measurement of P300. Accordingly, patients were assigned to the following four groups: cognitive impairment, non-cognitive impairment, mood disorder, and non-mood disorder.The amplitude and latency values of P300 were measured from the Pz, Fz, Fpz, C3, C4 and Cz electrode sites. In addition, correlations of P300 responses and neuropsychological test scores were analyzed.
Significant differences were found in the P300 latency values between the cognitive impairment group and non-cognitive impairment group (P<0.05). P300 latency values were more significantly prolonged in the mood disorder group at the Fz, C3 and Cz electrode sites than in the non-mood disorder group. Positive correlations were found between Hamilton Depression Scale scores and C3, Fz and Cz latencies. Females tended to have a statistically higher risk of emotional impairment than did males (p<0.05).
P300 latency values can be used as a objective indicator of cognitive impairments and mood disorders in CSVD patients.
脑小血管疾病（CSVDs）是认知障碍和情绪障碍的常见病因。近年来，事件相关电位P300作为认知障碍或情绪障碍的生物标志物受到越来越多的关注。以往关于P300的研究主要集中在焦虑、抑郁或认知障碍方面，关于CSVD患者P300的报道较少。本研究旨在探讨CSVD患者神经心理测试分数与P300之间的关系。
收集2016年6月至2017年10月在吉林大学第一医院神经内科病房收治的52例CSVD患者的临床资料。所有符合纳入标准的患者在入组后1周内接受认知测试和情绪量表评估，随后测量P300。据此，将患者分为以下四组：认知障碍组、非认知障碍组、情绪障碍组和非情绪障碍组。从Pz、Fz、Fpz、C3、C4和Cz电极部位测量P300的波幅和潜伏期值。此外，分析P300反应与神经心理测试分数的相关性。
认知障碍组与非认知障碍组之间P300潜伏期值存在显著差异（P<0.05）。情绪障碍组在Fz、C3和Cz电极部位的P300潜伏期值比非情绪障碍组延长更显著。汉密尔顿抑郁量表评分与C3、Fz和Cz潜伏期之间存在正相关。女性比男性在情绪障碍方面的风险在统计学上更高（p<0.05）。
P300潜伏期值可作为CSVD患者认知障碍和情绪障碍的客观指标。
