Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Trends Cell Biol. 2020 Jul;30(7):501-503. doi: 10.1016/j.tcb.2020.04.001. Epub 2020 Apr 15.
The elaborate control of biogenesis and turnover is essential for circular RNAs (circRNAs) to exert their functions properly in eukaryotic cells, whereas how circRNAs are degraded remains unclear. A recent study by Fischer et al. reveals a novel structure-mediated circRNA decay that selectively degrades highly structured RNAs by UPF1 and G3BP1.
真核细胞中精确的生物发生和周转控制对于环状 RNA（circRNA）发挥其功能至关重要，然而circRNA 的降解机制仍不清楚。Fischer 等人的一项最新研究揭示了一种新的结构介导的 circRNA 降解机制，该机制通过 UPF1 和 G3BP1 选择性地降解高度结构化的 RNA。
