前蛋白转化酶枯草溶菌素9（PCSK-9）抑制剂对通过近红外光谱评估的富含脂质的易损冠状动脉斑块的影响。 - Suppr

Effect of PCSK-9 Inhibitors on Lipid-Rich Vulnerable Coronary Plaque Assessed by Near-Infrared Spectroscopy.

作者信息

Omori Hiroyuki, Ota Hideaki, Hara Masahiko, Kawase Yoshiaki, Tanigaki Toru, Hirata Tetsuo, Sobue Yoshihiro, Okubo Munenori, Kamiya Hiroki, Matsuo Hitoshi

出版信息

JACC Cardiovasc Imaging. 2020 Jul;13(7):1639-1641. doi: 10.1016/j.jcmg.2020.02.019. Epub 2020 Apr 15.

DOI:10.1016/j.jcmg.2020.02.019

PMID:32305474

Abstract

摘要

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Effect of PCSK-9 Inhibitors on Lipid-Rich Vulnerable Coronary Plaque Assessed by Near-Infrared Spectroscopy.前蛋白转化酶枯草溶菌素9（PCSK-9）抑制剂对通过近红外光谱评估的富含脂质的易损冠状动脉斑块的影响。

JACC Cardiovasc Imaging. 2020 Jul;13(7):1639-1641. doi: 10.1016/j.jcmg.2020.02.019. Epub 2020 Apr 15.

Stabilization of High Risk Coronary Plaque on Optical Coherence Tomography and Near-Infrared Spectroscopy by Intensive Lipid-Lowering Therapy With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor.使用前蛋白转化酶枯草溶菌素/克新9型（PCSK9）抑制剂强化降脂治疗对光学相干断层扫描和近红外光谱下高危冠状动脉斑块的稳定作用

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Multimodality Intracoronary Imaging With Near-Infrared Spectroscopy and Intravascular Ultrasound in Asymptomatic Individuals With High Calcium Scores.高钙评分无症状个体的近红外光谱与血管内超声多模态冠状动脉成像

Circ Cardiovasc Imaging. 2017 Oct;10(10). doi: 10.1161/CIRCIMAGING.117.006282.

Quantitative optical coherence tomography tissue-type imaging for lipid-core plaque detection.用于脂质核心斑块检测的定量光学相干断层扫描组织类型成像。

JACC Cardiovasc Interv. 2013 Aug;6(8):891-2. doi: 10.1016/j.jcin.2012.11.015.

Plaque Characterization to Inform the Prediction and Prevention of Periprocedural Myocardial Infarction During Percutaneous Coronary Intervention: The CANARY Trial (Coronary Assessment by Near-infrared of Atherosclerotic Rupture-prone Yellow).基于近红外光检测易损斑块对经皮冠状动脉介入治疗围术期心肌梗死的预测与预防作用的研究：CANARY 试验（基于近红外光技术检测易损斑块的粥样硬化破裂倾向的黄色研究）。

JACC Cardiovasc Interv. 2015 Jun;8(7):927-36. doi: 10.1016/j.jcin.2015.01.032. Epub 2015 May 20.

High-density lipoprotein cholesterol associated with change in coronary plaque lipid burden assessed by near infrared spectroscopy.高密度脂蛋白胆固醇与近红外光谱评估的冠状动脉斑块脂质负担变化相关。

Atherosclerosis. 2017 Oct;265:110-116. doi: 10.1016/j.atherosclerosis.2017.08.016. Epub 2017 Aug 31.

Role of near-infrared spectroscopy in intravascular coronary imaging.近红外光谱在血管内冠状动脉成像中的作用。

Cardiovasc Revasc Med. 2015 Jul-Aug;16(5):299-305. doi: 10.1016/j.carrev.2015.06.001. Epub 2015 Jun 10.

Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study.血浆中分子脂质种类与冠状动脉斑块特征及心血管结局的关系：动脉粥样硬化斑块逆转-IVUS研究结果

Atherosclerosis. 2015 Dec;243(2):560-6. doi: 10.1016/j.atherosclerosis.2015.10.022. Epub 2015 Oct 23.

Near-Infrared Spectroscopy Enhances Intravascular Ultrasound Assessment of Vulnerable Coronary Plaque: A Combined Pathological and In Vivo Study.近红外光谱增强易损性冠状动脉斑块的血管内超声评估：联合病理和体内研究。

Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2423-31. doi: 10.1161/ATVBAHA.115.306118. Epub 2015 Sep 3.

Detection by near-infrared spectroscopy of large lipid core plaques at culprit sites in patients with acute ST-segment elevation myocardial infarction.近红外光谱技术在急性 ST 段抬高型心肌梗死患者罪犯部位检测大脂质核心斑块。

JACC Cardiovasc Interv. 2013 Aug;6(8):838-46. doi: 10.1016/j.jcin.2013.04.012. Epub 2013 Jul 17.

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Drug intervention as an emerging concept for secondary prevention in patients with coronary disease.药物干预作为冠心病二级预防的一个新兴概念。

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PCSK9 increases vulnerability of carotid plaque by promoting mitochondrial dysfunction and apoptosis of vascular smooth muscle cells.PCSK9 通过促进血管平滑肌细胞线粒体功能障碍和凋亡增加颈动脉斑块的易损性。

CNS Neurosci Ther. 2024 Feb;30(2):e14640. doi: 10.1111/cns.14640.

Soluble PCSK9 Inhibition: Indications, Clinical Impact, New Molecular Insights and Practical Approach-Where Do We Stand?可溶性前蛋白转化酶枯草溶菌素9抑制：适应证、临床影响、新分子见解及实践方法——我们目前的进展如何？

J Clin Med. 2023 Apr 18;12(8):2922. doi: 10.3390/jcm12082922.

Small Interfering Ribonucleic Acid as Lipid-Lowering Therapy: Inclisiran in Focus.小干扰核糖核酸作为降脂治疗药物：依洛尤单抗的焦点。

Int J Mol Sci. 2023 Mar 22;24(6):6012. doi: 10.3390/ijms24066012.

Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery.将动脉粥样硬化研究从实验室转化到临床：为有效的临床前药物发现扫清障碍。

Clin Sci (Lond). 2022 Dec 9;136(23):1731-1758. doi: 10.1042/CS20210862.

PCSK9 inhibitors for anti-inflammation in atherosclerosis: protocol for a systematic review and meta-analysis of randomised controlled trials.PCSK9 抑制剂在动脉粥样硬化中的抗炎作用：一项随机对照试验的系统评价和荟萃分析方案。

BMJ Open. 2022 Nov 24;12(11):e062046. doi: 10.1136/bmjopen-2022-062046.

Impact of PCSK9 Inhibition on Proinflammatory Cytokines and Matrix Metalloproteinases Release in Patients with Mixed Hyperlipidemia and Vulnerable Atherosclerotic Plaque.前蛋白转化酶枯草溶菌素9（PCSK9）抑制对混合性高脂血症和易损动脉粥样硬化斑块患者促炎细胞因子和基质金属蛋白酶释放的影响

Pharmaceuticals (Basel). 2022 Jun 27;15(7):802. doi: 10.3390/ph15070802.

Impact of Alirocumab on Release Markers of Atherosclerotic Plaque Vulnerability in Patients with Mixed Hyperlipidemia and Vulnerable Atherosclerotic Plaque.阿利西尤单抗对混合性高脂血症伴易损动脉粥样硬化斑块患者斑块易损性释放标志物的影响。

Medicina (Kaunas). 2022 Jul 21;58(7):969. doi: 10.3390/medicina58070969.

CENIT (Impact of Cardiac Exercise Training on Lipid Content in Coronary Atheromatous Plaques Evaluated by Near-Infrared Spectroscopy): A Randomized Trial.CENIT（近红外光谱评估心脏运动训练对冠状动脉粥样硬化斑块脂质含量的影响）：一项随机试验。

J Am Heart Assoc. 2022 May 17;11(10):e024705. doi: 10.1161/JAHA.121.024705. Epub 2022 May 16.

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